15
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S.-born black infants

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Standard values for birth weight by gestational age are not available for sub-Saharan Africa, but are needed to evaluate incidence and risk factors for intrauterine growth retardation in settings where HIV, antiretrovirals, and other in utero exposures may impact birth outcomes.

          Methods

          Birth weight data were collected from six hospitals in Botswana. Infants born to HIV-negative women between 26-44 weeks gestation were analyzed to construct birth weight for gestational age charts. These data were compared with published norms for black infants in the United States.

          Results

          During a 29 month period from 2007-2010, birth records were reviewed in real-time from 6 hospitals and clinics in Botswana. Of these, 11,753 live infants born to HIV-negative women were included in the analysis. The median gestational age at birth was 39 weeks (1 st quartile 38, 3 rd quartile 40 weeks), and the median birth weight was 3100 grams (1 st quartile 2800, 3 rd quartile 3400 grams). We constructed estimated percentile curves for birth weight by gestational age which demonstrate increasing slope during the third trimester and leveling off beyond 40 weeks. Compared with black infants in the United States, Botswana-born infants had lower median birth weight for gestational age from weeks 37 through 42 (p < .02).

          Conclusions

          We present birth weight for gestational age norms for Botswana, which are lower at term than norms for black infants in the United States. These findings suggest the importance of regional birth weight norms to identify and define risk factors for higher risk births. These data serve as a reference for Botswana, may apply to southern Africa, and may help to identify infants at risk for perinatal complications and inform comparisons among infants exposed to HIV and antiretrovirals in utero.

          Related collections

          Author and article information

          Journal
          BMC Pediatr
          BMC Pediatrics
          BioMed Central
          1471-2431
          2011
          16 December 2011
          : 11
          : 115
          Affiliations
          [1 ]Beth Israel Deaconess Medical Center, Division of Infectious Disease, 110 Francis Street, Lowry Medical Office Building - Suite GB, Boston, MA 02115, USA
          [2 ]Massachusetts General Hospital, Division of Infectious Disease, Center for Global Health, 100 Cambridge Street, Boston, MA, 02114, USA
          [3 ]Harvard School of Public Health, 651 Huntington Avenue, FXB Building - Room 509, Boston, MA 02115, USA
          [4 ]University of Miami, Miller School of Medicine, 1600 NW Tenth Avenue, Miami, FL 33136, USA
          [5 ]Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
          [6 ]Botswana Harvard AIDS Institute, Private Bag BO 320, Bontleng, Gaborone, Botswana
          [7 ]Brigham and Women's Hospital, Division of Infectious Disease, 75 Francis Street, Boston, MA 02115, USA
          [8 ]Harvard School of Public Health, Departments of Immunology and Infectious Disease, 651 Huntington Avenue, FXB Building - Room 401, Boston, MA 02115
          Article
          1471-2431-11-115
          10.1186/1471-2431-11-115
          3271964
          22176889
          b233d87d-1da5-4d30-87e8-f04ef717ff44
          Copyright ©2011 Matthews et al; licensee BioMed Central Ltd.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          History
          : 24 November 2010
          : 16 December 2011
          Categories
          Research Article

          Pediatrics
          Pediatrics

          Comments

          Comment on this article