NADPH oxidase 4 mediates the protective effects of physical activity against obesity-induced vascular dysfunction.

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Abstract

Physical activity is one of the most potent strategies to prevent endothelial dysfunction. Recent evidence suggests vaso-protective properties of hydrogen peroxide (H2O2) produced by main endothelial NADPH oxidase isoform 4 (Nox4) in the vasculature. Therefore, we hypothesized that Nox4 connects physical activity with vaso-protective effects.

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Journal

Journal ID (iso-abbrev): Cardiovasc Res

Title: Cardiovascular research

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1755-3245

ISSN (Print): 0008-6363

Publication date (Electronic): Aug 01 2020

Volume: 116

Issue: 10

Affiliations

[1 ] Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany.

[2 ] Department of Medicine III, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany.

Article

Publisher Item ID: 5652189

DOI: 10.1093/cvr/cvz322

PubMed ID: 31800011

SO-VID: b241487f-c174-4c0c-ae76-8da05972ae97

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Keywords: Exercise,Endothelial function,Nox4,Voluntary running,Vascular function,NADPH oxidase 4

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Keywords: Exercise, Endothelial function, Nox4, Voluntary running, Vascular function, NADPH oxidase 4

NADPH oxidase 4 mediates the protective effects of physical activity against obesity-induced vascular dysfunction.

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