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      NADPH oxidase 4 mediates the protective effects of physical activity against obesity-induced vascular dysfunction.

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          Abstract

          Physical activity is one of the most potent strategies to prevent endothelial dysfunction. Recent evidence suggests vaso-protective properties of hydrogen peroxide (H2O2) produced by main endothelial NADPH oxidase isoform 4 (Nox4) in the vasculature. Therefore, we hypothesized that Nox4 connects physical activity with vaso-protective effects.

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          Author and article information

          Journal
          Cardiovasc Res
          Cardiovascular research
          Oxford University Press (OUP)
          1755-3245
          0008-6363
          Aug 01 2020
          : 116
          : 10
          Affiliations
          [1 ] Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
          [2 ] Department of Medicine III, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany.
          Article
          5652189
          10.1093/cvr/cvz322
          31800011

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