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      Evaluation of White Sesame Seed Oil on Glucose Control and Biomarkers of Hepatic, Cardiac, and Renal Functions in Male Sprague-Dawley Rats with Chemically Induced Diabetes

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          Abstract

          White sesame seed oil (WSSO) has been used in cooking and food preparations for centuries. It has many purported health benefits and may be a promising nutraceutical. The primary purpose of this study was to examine the effects of WSSO on fasting blood glucose (GLU) and insulin (INS) in male Sprague-Dawley rats with chemically induced diabetes. A secondary aim was to explore other hematological biomarkers of hepatic, cardiac, and renal function. Sixty-three male Sprague-Dawley rats were randomized into standard diet groups, normal control (NCON) ( n = 21) and diabetic control (DCON) ( n = 21), and a diabetic sesame oil (DSO) ( n = 21) group, which were fed a diet containing 12% WSSO. Blood samples were analyzed at 0, 30, and 60 days. Differences between groups and across days were assessed with two-way repeated measures analysis of variance. At baseline, GLU and INS were similar in both diabetic groups, mean 248.4 ± 2.8 mg/dL and mean 23.4 ± 0.4 μU/mL, respectively. At 60 days, GLU was significantly ( P < .05) higher in DCON (298.0 ± 2.3 mg/dL) compared with DSO (202.1 ± 1.0 mg/dL). INS showed similar favorable trends after WSSO supplementation. Consumption of WSSO significantly improved glucose control and other biomarkers of hepatic stress, as well as cardiac and renal health. WSSO may be a viable functional food to help reduce the detrimental effects of diabetes.

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          Author and article information

          Journal
          J Med Food
          J Med Food
          jmf
          Journal of Medicinal Food
          Mary Ann Liebert, Inc. (140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA )
          1096-620X
          1557-7600
          01 May 2017
          01 May 2017
          : 20
          : 5
          : 448-457
          Affiliations
          [ 1 ]Department of Food Science and Human Nutrition, Faculty of Biosciences, University of Veterinary and Animal Sciences Lahore , Lahore, Pakistan.
          [ 2 ]Department of Microbiology, Faculty of Veterinary Sciences, University of Veterinary and Animal Sciences Lahore , Lahore, Pakistan.
          [ 3 ]School of Nutrition and Health Promotion, Arizona State University , Phoenix, Arizona.
          Author notes
          Address correspondence to: Sanaullah Iqbal, PhD, Department of Food Science and Human Nutrition, Faculty of Biosciences, University of Veterinary and Animal Sciences Lahore, Syed Abdul Qadir Jillani (Out Fall) Road, Lahore, 54000, Pakistan, E-mail: sanaullah.iqbal@ 123456uvas.edu.pk
          Article
          PMC5444487 PMC5444487 5444487 10.1089/jmf.2016.0065
          10.1089/jmf.2016.0065
          5444487
          28332903
          b262a936-c1f9-448f-8739-e034a6fffb3d
          Copyright 2017, Mary Ann Liebert, Inc., and Korean Society of Food Science and Nutrition
          Page count
          Figures: 4, Tables: 3, References: 49, Pages: 10
          Categories
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