9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Relationship of oxygen dose to angiogenesis induction in irradiated tissue.

      1 , , ,
      American journal of surgery
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p = 0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p = 0.001). Irradiated tissue develops a hypovascular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.

          Related collections

          Author and article information

          Journal
          Am J Surg
          American journal of surgery
          Elsevier BV
          0002-9610
          0002-9610
          Nov 1990
          : 160
          : 5
          Affiliations
          [1 ] Division of Oral and Maxillofacial Surgery, University of Miami School of Medicine/Jackson Memorial Medical Center, Florida.
          Article
          S0002-9610(05)81019-0
          10.1016/s0002-9610(05)81019-0
          2240387
          b262e9ae-4aaf-49ab-bc3b-7d58b5b59bd3
          History

          Comments

          Comment on this article