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      Bio-Based Solvents for Green Extraction of Lipids from Oleaginous Yeast Biomass for Sustainable Aviation Biofuel

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      Molecules
      MDPI
      yeast, lipids, COSMO-RS, Hansen, bio-based solvents

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          Abstract

          Lipid-based oleaginous microorganisms are potential candidates and resources for the sustainable production of biofuels. This study was designed to evaluate the performance of several alternative bio-based solvents for extracting lipids from yeasts. We used experimental design and simulation with Hansen solubility simulations and the conductor-like screening model for realistic solvation (COSMO-RS) to simulate the solubilization of lipids in each of these solvents. Lipid extracts were analyzed by high performance thin-layer chromatography (HPTLC) to obtain the distribution of lipids classes and gas chromatography coupled with a flame ionization detector (GC/FID) to obtain fatty acid profiles. Our aim was to correlate simulation with experimentation for extraction and solvation of lipids with bio-based solvents in order to make a preliminary evaluation for the replacement of hexane to extract lipids from microorganisms. Differences between theory and practice were noted for several solvents, such as CPME, MeTHF and ethyl acetate, which appeared to be good candidates to replace hexane.

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          Most cited references15

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          COSMO-RS: an alternative to simulation for calculating thermodynamic properties of liquid mixtures.

          The conductor-like screening model for realistic solvation (COSMO-RS) method has been established as a novel way to predict thermophysical data for liquid systems and has become a frequently used alternative to force field-based molecular simulation methods on one side and group contribution methods on the other. Through its unique combination of a quantum chemical treatment of solutes and solvents with an efficient statistical thermodynamics procedure for the molecular surface interactions, it enables the efficient calculation of many properties that other methods can barely predict. This review presents a short delineation of the theory, the application potential and limitations of COSMO-RS, and its most important application areas.
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            Alternative Bio-Based Solvents for Extraction of Fat and Oils: Solubility Prediction, Global Yield, Extraction Kinetics, Chemical Composition and Cost of Manufacturing

            The present study was designed to evaluate the performance of alternative bio-based solvents, more especially 2-methyltetrahydrofuran, obtained from crop’s byproducts for the substitution of petroleum solvents such as hexane in the extraction of fat and oils for food (edible oil) and non-food (bio fuel) applications. First a solvent selection as well as an evaluation of the performance was made with Hansen Solubility Parameters and the COnductor-like Screening MOdel for Realistic Solvation (COSMO-RS) simulations. Experiments were performed on rapeseed oil extraction at laboratory and pilot plant scale for the determination of lipid yields, extraction kinetics, diffusion modeling, and complete lipid composition in term of fatty acids and micronutrients (sterols, tocopherols and tocotrienols). Finally, economic and energetic evaluations of the process were conducted to estimate the cost of manufacturing using 2-methyltetrahydrofuran (MeTHF) as alternative solvent compared to hexane as petroleum solvent.
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              Microorganisms for lipids

              C Ratledge (1991)
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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Molecules
                Molecules
                molecules
                Molecules
                MDPI
                1420-3049
                06 February 2016
                February 2016
                : 21
                : 2
                : 196
                Affiliations
                Laboratoire GREEN, Université d’Avignon, Vaucluse, INRA, UMR 408, GREEN Extraction Team, F-84000 Avignon, France; cassandra.breil@ 123456alumni.univ-avignon.fr (C.B.); alice.meullemiestre@ 123456univ-avignon.fr (A.M.); farid.chemat@ 123456univ-avignon.fr (F.C.)
                Author notes
                [* ]Correspondence: maryline.vian@ 123456univ-avignon.fr ; Tel.: +33-490-144-432
                [†]

                These authors contributed equally to this work.

                Article
                molecules-21-00196
                10.3390/molecules21020196
                6274296
                26861274
                b2738c6d-e321-4d1d-97fd-64c6fae059e3
                © 2016 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 11 December 2015
                : 26 January 2016
                Categories
                Article

                yeast,lipids,cosmo-rs,hansen,bio-based solvents
                yeast, lipids, cosmo-rs, hansen, bio-based solvents

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