Infodemic is defined as an information epidemic that can lead to engaging in dangerous behavior. Although the most striking manifestations of the latter occurred on social media, some studies show that dismisinformation is significantly influenced by numerous additional factors, both web-based and offline. These include social context, age, education, personal knowledge and beliefs, mood, psychological defense mechanisms, media resonance, and how news and information are presented to the public. Moreover, various incorrect scientific practices related to disclosure, publication, and training can also fuel such a phenomenon. Therefore, in this opinion article, we seek to provide a comprehensive overview of the issues that need to be addressed to bridge the gap between science and the public and build resilience to the infodemic. In particular, we stress that the infodemic cannot be curbed by simply disproving every single false or misleading information since the belief system and the cultural or educational background are chief factors regarding the success of fake news. For this reason, we believe that the process of forming a critical sense should begin with children in schools (ie, when the mind is more receptive to new ways of learning). Furthermore, we also believe that themes such as scientific method and evidence should be at the heart of the university education of a future scientist. Indeed, both the public and scientists must be educated on the concepts of evidence and validity of sources, as well as learning how to dialogue appropriately with each other. Finally, we believe that the scientific publishing process could be greatly improved by paying reviewers for their work and by ceasing to pursue academic success at all costs.
