For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
16
views
2
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      327
      similar
       All similar

      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

      Submit here before July 31, 2024

      About Blood Purification: 3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)

      • Record: found
      • Abstract: found
      • Article: found

      Effect of the Platelet-Derived Growth Factor Antagonist Trapidil on Mesangial Cell Proliferation in Rats

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Platelet-derived growth factor (PDGF) is known as a potent mediator in the proliferation of mesangial cells in culture and in mesangial proliferative nephritis. The present study was undertaken to evaluate the effect of trapidil, an antagonist of PDGF, on mesangial cell proliferation in culture and in anti-Thy-1.1 nephritis in rats. Trapidil significantly inhibited <sup>3</sup>H-thymidine incorporation in the mesangial cells stimulated by PDGF BB and suppressed mesangial cell proliferation in culture in a dose-dependent manner. In anti-Thy-1.1 nephritis, a significant reduction in the number of total glomerular cells and also proliferating (proliferating cell nuclear antigen positive) cells was demonstrated on day 7 in the rats treated with trapidil as compared with controls. Although renal function expressed as blood urea nitrogen and creatinine levels did not differ between rats with and without trapidil treatment, the present results suggest a salutary effect of trapidil on mesangial cell proliferation. PDGF, therefore, could play an important role in mediating mesangial cell proliferation.

          Related collections

          Most cited references2

          • Record: found
          • Abstract: found
          • Article: not found

          Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta.

          R Bravo, Graeme Frank, P Blundell … (2015)
          Identification of the cellular proteins whose expression is regulated during the cell cycle in normal cells is essential for understanding the mechanisms involved in the control of cell proliferation. A nuclear protein called cyclin of relative molecular mass 36,000 (Mr 36K), whose synthesis correlates with the proliferative state of the cell, has been identified in several cell types of human, mouse, hamster and avian origin. The rate of cyclin synthesis is very low in quiescent cells and increases several fold after serum stimulation shortly before DNA synthesis. Immunofluorescence and autoradiography studies have shown that the nuclear staining patterns of cyclin during S phase have a sequential order of appearance and a clear correlation can be found between DNA synthesis and cyclin positive nuclei. The proliferating cell nuclear antigen (PCNA) and cyclin have many common properties and it has been shown that these two are identical. Recently a protein which is required by DNA polymerase-delta for its catalytic activity with templates having low primer/template ratios has been isolated from calf thymus. We report here that cyclin and the auxiliary protein of DNA polymerase-delta are identical.
          Article 0 comments Cited 124 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            A new approach to the treatment of atherosclerosis and trapidil as an antagonist to platelet-derived growth factor

            H Ohnishi, K. Yamaguchi, S Shimada … (1981)
            Article 0 comments Cited 5 times – based on 0 reviews     Review now
              Bookmark
              All references

              Author and article information

              Journal
              Journal ID (publisher-id): NEF
              Journal ID (nlm-ta): Nephron
              Journal ID (doi): 10.1159/issn.1660-8151
              Title: Nephron
              Publisher: S. Karger AG
              ISSN (Print): 1660-8151
              ISSN (Electronic): 2235-3186
              Publication date Subscription-year: 1999
              Publication date (Print): April 1999
              Publication date (Electronic): 31 March 1999
              Volume: 81
              Issue: 4
              Pages: 428-433
              Affiliations
              a2nd Department of Internal Medicine, Toyama Medical and Pharmaceutical University, and bDepartment of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan
              Article
              Publisher ID: 45327 Other ID: Nephron 1999;81:428–433
              DOI: 10.1159/000045327
              PubMed ID: 10095179
              SO-VID: b29d3a7f-896a-401e-b866-5239dcc76956
              Copyright © © 1999 S. Karger AG, Basel
              License:

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              History
              Page count
              Figures: 4, Tables: 1, References: 25, Pages: 6
              Categories
              Subject: Original Paper

              ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
              Keywords: Mesangial cell proliferation,Anti-Thy-1.1 nephritis,Platelet-derived growth factor
              Data availability:
              ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
              Keywords: Mesangial cell proliferation, Anti-Thy-1.1 nephritis, Platelet-derived growth factor

              Comments

              Comment on this article