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      Nanotechnology-based therapeutic applications: in vitro and in vivo clinical studies for diabetic wound healing.

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          Abstract

          Diabetic wounds often indicate chronic complications that are difficult to treat. Unfortunately, existing conventional treatment modalities often cause unpremeditated side effects, given the need to develop alternative therapeutic phenotypes that are safe or have minimal side effects and risks. Nanotechnology-based platforms, including nanotherapeutics, nanoparticles (NPs), nanofibers, nanohydrogels, and nanoscaffolds, have garnered attention for their groundbreaking potential to decipher the biological environment and offer personalized treatment methods for wound healing. These nanotechnology-based platforms can successfully overcome the impediments posed by drug toxicity, existing treatment modalities, and the physiology and complexity of the wound sites. Furthermore, studies have shown that they play an essential role in influencing angiogenesis, collagen production, and extracellular matrix (ECM) synthesis, which are integral in skin repair mechanisms. In this review, we emphasized the importance of various nanotechnology-based platforms for healing diabetic wounds and report on the innovative preclinical and clinical outcomes of different nanotechnology-based platforms. This review also outlined the limitations of existing conventional treatment modalities and summarized the physiology of acute and chronic diabetic wounds.

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          Author and article information

          Journal
          Biomater Sci
          Biomaterials science
          Royal Society of Chemistry (RSC)
          2047-4849
          2047-4830
          Nov 23 2021
          : 9
          : 23
          Affiliations
          [1 ] Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia. sheikh.haque@monash.edu.
          [2 ] Department of Biochemistry and Molecular Medicine, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.
          [3 ] Department of Stem Cell and Regenerative Biotechnology, Incurable Disease Animal Model & Stem Cell Institute (IDASI), Konkuk University, 120 Neugdong-ro, Gwangjin-gu, Seoul 05029, Korea. subbroto1986@gmail.com.
          [4 ] Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh. enamulmd@du.ac.bd.
          [5 ] Department of Surgery, Indiana University School of Medicine, Indianapolis, IN-46202, USA.
          [6 ] Department of Immunology and Microbial Diseases, Albany Medical College, Albany, NY-12208, USA. biswasn@amc.edu.
          Article
          10.1039/d1bm01211h
          34709244
          b29e882b-1707-4853-8b3a-57089b5a2582
          History

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