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      Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

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          Abstract

          Until now, polymyxin resistance has involved chromosomal mutations but has never been reported via horizontal gene transfer. During a routine surveillance project on antimicrobial resistance in commensal Escherichia coli from food animals in China, a major increase of colistin resistance was observed. When an E coli strain, SHP45, possessing colistin resistance that could be transferred to another strain, was isolated from a pig, we conducted further analysis of possible plasmid-mediated polymyxin resistance. Herein, we report the emergence of the first plasmid-mediated polymyxin resistance mechanism, MCR-1, in Enterobacteriaceae.

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          Author and article information

          Journal
          Lancet Infect Dis
          The Lancet. Infectious diseases
          Elsevier BV
          1474-4457
          1473-3099
          Feb 2016
          : 16
          : 2
          Affiliations
          [1 ] College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, South China Agricultural University, Guangzhou, China.
          [2 ] Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
          [3 ] Department of Medical Microbiology and Infectious Disease, Institute of Infection & Immunity, Heath Park Hospital, Cardiff, UK.
          [4 ] The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China.
          [5 ] School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, UK.
          [6 ] Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
          [7 ] Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China.
          [8 ] College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, South China Agricultural University, Guangzhou, China. Electronic address: jhliu@scau.edu.cn.
          [9 ] Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address: sjz@cau.edu.cn.
          Article
          S1473-3099(15)00424-7
          10.1016/S1473-3099(15)00424-7
          26603172
          b2a7ceab-d863-4091-b2bc-325c6db3c17b
          Copyright © 2016 Elsevier Ltd. All rights reserved.
          History

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