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      Effect of Narcotic Analgesics and Naloxone on Proestrous Surges of LH, FSH and Prolactin in Rats

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      Neuroendocrinology

      S. Karger AG

      Morphine, Naloxone, Proestrous gonadotropin surges

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          Abstract

          Morphine (50 mg/kg), given at 12:00 h and 14:00 h to proestrous rats, completely inhibited the proestrous surges of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (Prl). However, when it was given at 16:00 h, the inhibitory effect of morphine (Mor) was decreased. Pethidine and nalorphine inhibited the proestrous surges, while pentazocine showed a weaker inhibitory effect. Naloxone (Nx), given simultaneously or 2 h after morphine (Mor), at 1/20 the dose of Mor, inhibited the blockade of the proestrous gonadotropin release exerted by Mor, while the onset of the surges was delayed when it was given 3 h after Mor.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1979
          1979
          26 March 2008
          : 28
          : 4
          : 241-247
          Affiliations
          Department of Pharmacology, School of Medicine, Keio University, Tokyo
          Article
          122868 Neuroendocrinology 1979;28:241–247
          10.1159/000122868
          35761
          © 1979 S. Karger AG, Basel

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          Pages: 7
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