We show that in SO(10) models, a Yukawa sector consisting of a real \(10_H\), a real \(120_H\) and a complex \(126_H\) of Higgs fields can provide a realistic fit to all fermion masses and mixings, including the neutrino sector. Although the group theory of SO(10) demands that the \(10_H\) and \(120_H\) be real, most constructions complexify these fields and impose symmetries exterior to SO(10) to achieve predictivity. The proposed new framework with real \(10_H\) and real \(120_H\) relies only on SO(10) gauge symmetry, and yet has a limited number of Yukawa parameters. Our analysis shows that while there are restrictions on the observables, a good fit to the entire fermion spectrum can be realized. Unification of gauge couplings is achieved with an intermediate scale Pati-Salam gauge symmetry. Proton decay branching ratios are calculable, with the leading decay modes being \(p \rightarrow \overline{\nu} \pi^+\) and \(p \rightarrow e^+ \pi^0\).