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Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction: ATLANTIC-Morphine
Frédéric Lapostolle ,
Arnoud W. van’t Hof ,
Christian W. Hamm ,
Olivier Stibbe ,
Patrick Ecollan ,
Jean-Philippe Collet ,
Johanne Silvain ,
Jens Flensted Lassen ,
Wim M. J. M. Heutz ,
Leonardo Bolognese ,
Warren J. Cantor ,
Angel Cequier ,
Mohamed Chettibi ,
Shaun G. Goodman ,
Christopher J. Hammett ,
Kurt Huber ,
Magnus Janzon ,
Béla Merkely ,
Robert F. Storey ,
Jur ten Berg ,
Uwe Zeymer ,
Muriel Licour ,
Anne Tsatsaris ,
Gilles Montalescot ,
for the ATLANTIC Investigators
October 23 2018
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Abstract
<p class="first" id="d9824522e414">Morphine adversely impacts the action of oral adenosine
diphosphate (ADP)-receptor
blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly
associated with differing patient characteristics. This retrospective analysis investigated
whether interaction between morphine use and pre-percutaneous coronary intervention
(pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study
was associated with differences in patient characteristics and management.
</p>