Mean platelet volume (MPV) is an indicator of platelet function or reactivity. Platelets
play an important role in the pathophysiology of ischemic stroke but the effect of
platelet count (PC) and dysfunction in the pathogenesis of hemorrhagic stroke is poorly
understood. We have investigated the possibility of MPV and PC being an independent
risk factor of ischemic and haemorrhagic stroke and their effect on prognosis.
We prospectively studied 692 patients with either ischemic or hemorrhagic stroke and
compared them with 208 control subjects with similar risk factors, but without evidence
of vascular events. The association of MPV and PC with cause, localization, and size
of the infarct or hemorrhage was examined. Prognosis was determined by Glasgow Outcome
Scale. By multivariate logistic regression analysis, the influence of MPV and PC on
stroke subtype and prognosis was determined.
MPV and PC were observed as independent risk factors for ischemic stroke (P = .007,
odds ratio [OR] = 0.866; P = .000, OR = 0.996; 95% confidence interval [CI], respectively).
There was a negative and significant correlation between PC and hemorrhagic stroke
(P = .001), but no association was found with MPV (P > .05). MPV and PC were not statistically
significant related to etiological subgroups, localization, and size of the infarct
or hemorrhage (P > .05). Ischemic group MPV (P = .013, OR = 1.02, 95% CI) and hemorrhagic
group PC were in correlation with worse outcome (P = .001, OR = 1.004, 95% CI).
MPV, may be an early and important predictor for the prognosis of ischemic stroke,
whereas for hemorrhagic stroke PC has a role for outcome.
(c) 2010. Published by Elsevier Inc.