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      Variations of Lacrimal Fluid Peroxidase Activity in Female and Male Rats

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          Abstract

          Previous research from this laboratory showed that human lacrimal fluid peroxidase has cyclic variations during the menstrual cycle, correlated with plasma levels of 17β-oestradiol. In the present investigation, variations of enzyme activity and total protein content during the oestrous cycle of young adult female rats are analysed. Effects from circadian rhythm and a gender-related influence are also examined. In female rats, as in women, lacrimal fluid peroxidase activity shows cyclic variations; in fact, it significantly (p < 0.05) changes during the different phases of the oestrous cycle. In contrast, in males such variations do not occur. Thus, we suggest that gender seems to exert a significant influence on the secretion of this specific tear protein, probably by a direct effect of oestrogens.

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          Alpha 1-adrenergic agonist-stimulated protein secretion in rat exorbital lacrimal gland acini.

          D Dicker, P. Rose, A Ronco … (1994)
          The alpha-adrenergic stimulation by phenylephrine of lacrimal gland protein secretion was pharmacologically characterized. Acini, prepared from rat exorbital lacrimal glands, were incubated with agonists, antagonists or both for 0-20 min. Peroxidase secretion, an index of protein secretion, was measured spectrophotometrically. Peroxidase secretion was stimulated by the alpha 1-adrenergic agonists clonidine. The non-selective alpha-adrenergic antagonist phentolamine completely inhibited phenylephrine-induced secretion. The selective alpha 1-adrenergic alkylating agent phenoxybenzamine and the selective alpha 1-adrenergic antagonist prazosin partially inhibited phenylephrine-induced secretion. The alpha 2-adrenergic antagonist yohimbine, the beta-adrenergic antagonist timolol, and the dopaminergic antagonist haloperidol also inhibited phenylephrine-induced secretion but were 100-fold less potent than prazosin. It is concluded that phenylephrine activates an alpha 1-adrenergic pathway, but not an alpha 2-adrenergic, beta-adrenergic or dopaminergic pathway, to stimulate lacrimal gland protein secretion from acini.
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            Author and article information

            Journal
            Journal ID (publisher-id): ORE
            Journal ID (nlm-ta): Ophthalmic Res
            Journal ID (doi): 10.1159/issn.0030-3747
            Title: Ophthalmic Research
            Publisher: S. Karger AG
            ISSN (Print): 0030-3747
            ISSN (Electronic): 1423-0259
            Publication date Subscription-year: 2001
            Publication date (Print): June 2001
            Publication date (Electronic): 04 May 2001
            Volume: 33
            Issue: 3
            Pages: 176-179
            Affiliations
            aDipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, Università degli Studi di Roma ‘La Sapienza’, Roma, e bDipartimento di Biologia di Base ed Applicata, Università de L’Aquila, Italia
            Article
            Publisher ID: 55666 Other ID: Ophthalmic Res 2001;33:176–179
            DOI: 10.1159/000055666
            PubMed ID: 11340410
            SO-VID: b3339ca5-7903-4cd5-b17b-9abc8c487d57
            Copyright © © 2001 S. Karger AG, Basel
            License:

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Page count
            Figures: 1, Tables: 1, References: 16, Pages: 4
            Categories
            Subject: Original Paper

            ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
            Keywords: Mammalian peroxidase,Oestrous cycle,Lacrimal secretion,17β-Oestradiol
            Data availability:
            ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
            Keywords: Mammalian peroxidase, Oestrous cycle, Lacrimal secretion, 17β-Oestradiol

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