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The Adrenergic Innervation of Intrarenal Glomerular and Extra-Glomerular Circulatory Routes
Abstract
The vasculature of the arteriole-glomerular units in variou« zones of the rat kidney was studied by micro-angiography, and the adrenergic innervation of these units by the histochemical fluorescence method for biogenic monoamines. In the cortical unit the afferent arteriole, glomerular tuft and efferent arteriole are coupled in series, whereas in the juxtamedullary unit the glomerular capillaries bud off as lateral twigs from a continuous arteriole which leads into the medulla. These findings of an extraglomerular medullary circulation have previously been demonstrated in man and rabbit. The cortical and juxtamedullary units have similar innervation patterns with adrenergic nerve terminals along both the afferent and efferent arterioles. These findings agree with evidences presented by others of neurogenic contractions of both pre- and postglomerular vessels. The adrenergic innervation of the continuous juxtamedullary arterioles constitutes a morphological basis for neurogenic variations in the magnitude of the extraglomerular circulation in the kidney with consequent changes of GFR and FF.
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179824 Nephron 1970;7:218–229Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.