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      Diagnosis and classification of sporadic inclusion body myositis (sIBM).

      1 , 2 , 3
      Autoimmunity reviews
      Elsevier BV
      Inclusion body, Inflammation, Myopathy, Myositis

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          Abstract

          Sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease in elderly individuals, particularly men. Its prevalence varies among ethnic groups but is estimated at 35 per one million people over 50. Genetic as well as environmental factors and autoimmune processes might both have a role in its pathogenesis. Unlike other inflammatory myopathies, sIBM causes very slowly progressive muscular weakness and atrophy, having a distinctive pattern of muscle involvement and different forms of clinical presentation. In some cases a primary autoimmune disease coexists. Diagnosis is suspected on clinical grounds and is established by typical muscle pathology. As a rule sIBM is refractory to conventional forms of immunotherapy.

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          Author and article information

          Journal
          Autoimmun Rev
          Autoimmunity reviews
          Elsevier BV
          1873-0183
          1568-9972
          January 16 2014
          : 13
          : 4-5
          Affiliations
          [1 ] Fundació Privada Cellex, University of Barcelona, Spain. Electronic address: macatala@clinic.ub.es.
          [2 ] Internal Medicine Service, Hospital Vall d'Hebrón, Barcelona, Spain. Electronic address: aselva@vhebron.net.
          [3 ] Fundació Privada Cellex, University of Barcelona, Spain; Internal Medicine Service, Hospital Clínic of Barcelona, University of Barcelona, Spain. Electronic address: jmgrau@clinic.ub.es.
          Article
          S1568-9972(14)00028-7
          10.1016/j.autrev.2014.01.016
          24424185
          b3367c0d-f993-48c5-b2c3-991c6fdd5555
          History

          Inclusion body,Inflammation,Myopathy,Myositis
          Inclusion body, Inflammation, Myopathy, Myositis

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