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      Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy

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      Cancer Discovery
      American Association for Cancer Research (AACR)

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          Abstract

          Personalized oncology aims to tailor therapy by targeting the unique genetic characteristics of a patient's tumor, whereas cancer immunotherapy focuses on activating the patient's immune system to control the tumor. The fusion of these ostensibly separate strategies has created a new dimension for personalized cancer immunotherapy. This entails the development of next-generation cancer vaccines that target neoantigens as well as the use of mutational signatures as predictive biomarkers for clinical response. The optimal use of immunotherapeutic agents will hinge on a robust understanding of the mutational profile of a cancer's genome that significantly dictates antitumor immunity and immunotherapeutic response.

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          Author and article information

          Journal
          Cancer Discovery
          Cancer Discovery
          American Association for Cancer Research (AACR)
          2159-8274
          2159-8290
          June 30 2016
          April 22 2016
          : 6
          : 7
          : 703-713
          Article
          10.1158/2159-8290.CD-16-0146
          4930745
          27107038
          b33bc258-b479-4d27-9829-8206f3256acc
          © 2016
          History

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