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      Alternative Methods to Treat Nausea and Vomiting from Cancer Chemotherapy

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          Abstract

          Chemotherapy Induced Nausea and Vomiting (CINV) is among the most intensive side effects and critical concerns for patients with cancer. Most of these patients experience nausea and vomiting after chemotherapy. Sometimes, this is so annoying that it may prevent them from continuing the therapy. With the recent advances, a variety of therapeutic methods are innovated and applied to control CINV. Among them, the main methods include medicinal therapy, relaxation, and herbal therapy. Yet, using dexamethasone together with massage therapy and ginger is identified as the most effective method.

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          Effects of ginger capsules on pregnancy, nausea, and vomiting.

          Giti Ozgoli, D Goli, Masoumeh Simbar (2009)
          The aim of this study was to determine the effects of ginger in nausea and vomiting of pregnancy. This was a single blind clinical trial study. The study was conducted in a selected prenatal care clinic of Isfahan City hospitals. The subjects included 67 pregnant women who complained of nausea and vomiting from Isfahan city hospitals participated in the study. The participants were randomly assigned to two groups, an experimental group and a control group. The groups were matched according to the age, gestational age, parity, occupational status, and educational level of the participants. The experimental group received ginger 250 mg capsules for 4 days, and the control group received placebo with the same prescription form. Effects of treatment of nausea were evaluated twice daily for 4 days by a before-and-after treatment questionnaire. The mean ages of the experimental and control groups were 24.1 +/- 4.8 and 23.3 +/- 5 years, respectively. The mean gestational age was 13 +/- 3 weeks, and the mean parity was 1.6 +/- 0.8. The ginger users demonstrated a higher rate of improvement than the placebo users did (85% versus 56%; p < 0.01). The decrease in vomiting times among ginger users was also significantly greater than among the women who received the placebo (50% versus 9%; p < 0.05). A daily total of 1000 mg of ginger in a capsule preparation can be suggested by care providers as a means of decreasing pregnancy nausea and vomiting in women who tend to herbal medicines. Ginger is an effective herbal remedy for decreasing nausea and vomiting during pregnancy.
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            Protein and ginger for the treatment of chemotherapy-induced delayed nausea.

            Sara Koch, Lucy G. Gillis, Keith E Levine … (2008)
            Nausea that develops during the period that begins 24 hours after the administration of chemotherapy is called delayed nausea, and occurs in many patients with cancer. Meals high in protein decrease the nausea of motion sickness and pregnancy, possibly by reducing gastric dysrhythmias. Ginger also has antinausea properties. To explore the use of protein meals with ginger for the treatment of the delayed nausea of chemotherapy. Twenty-eight (28) patients with cancer receiving chemotherapy for the first time were assigned to 1 of 3 groups. For 3 days beginning the day after their chemotherapy, Control Group patients continued with their normal diet, Protein Group patients consumed a protein drink and ginger twice daily, and High Protein Group patients consumed a protein drink with additional protein and ginger twice daily. Patients recorded in a diary each day whether they had experienced nausea, whether their nausea had been frequent, whether their nausea had been bothersome, and whether they had needed any antiemetic medication. Gastric myoelectrical activity was assessed in 5 patients before and after ingestion of a high protein meal and ginger. Reports of nausea, frequent nausea, and bothersome nausea were significantly less common among High Protein Group patients than among Control and Protein Group patients. Furthermore, significantly fewer patients in the High Protein Group used antiemetic medication. Differences between the Protein and Control groups were not statistically significant. In the 5 patients who had tests of gastric myoelectrical activity performed, a significant decrease in gastric dysrhythmia occurred after ingestion of the protein and ginger. High protein meals with ginger reduced the delayed nausea of chemotherapy and reduced use of antiemetic medications. Protein with ginger holds the potential of representing a novel, nutritionally based treatment for the delayed nausea of chemotherapy.
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              Ginger does not prevent postoperative nausea and vomiting after laparoscopic surgery.

              W Seeling, Rory Mayer, Leopold Eberhart … (2003)
              The potential antiemetic effect of two different oral doses of the herbal remedy ginger (Zingiber officinale) to prevent postoperative nausea and vomiting in 180 patients undergoing gynecologic laparoscopy was investigated in this randomized, double-blinded trial. Ginger failed to reduce the incidence of postoperative nausea and vomiting after these procedures.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Chemother Res Pract
                Journal ID (iso-abbrev): Chemother Res Pract
                Journal ID (publisher-id): CHERP
                Title: Chemotherapy Research and Practice
                Publisher: Hindawi Publishing Corporation
                ISSN (Print): 2090-2107
                ISSN (Electronic): 2090-2115
                Publication date (Print): 2015
                Publication date (Electronic): 8 November 2015
                Volume: 2015
                Electronic Location Identifier: 818759
                Affiliations
                1Department of Cardiac Surgery, Atherosclerosis Research Center Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
                2Department of Cardiac Anesthesiology, Atherosclerosis Research Center Golestan Hospital and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
                3Division of Surgery, Emam Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
                4Department of Toxicology, Islamic Azad University, Shahreza Branch and Medical Research Center, Jundishapur Health Development Co., Tehran, Iran
                Author notes
                *Hossein Rahmani: r.h1989@ 123456yahoo.com

                Academic Editor: Vito Lorusso

                Article
                DOI: 10.1155/2015/818759
                PMC ID: 4655029
                PubMed ID: 26634155
                SO-VID: b341ea8a-d7fc-4ea4-913d-071877bf93a3
                Copyright © Copyright © 2015 Mohammad Ali Sheikhi et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 31 May 2015
                Date revision received : 9 September 2015
                Date accepted : 10 September 2015
                Categories
                Subject: Review Article

                ScienceOpen disciplines: Oncology & Radiotherapy
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy

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