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      Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.

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          Abstract

          In the past decade, palladium-catalyzed C-H activation/C-C bond-forming reactions have emerged as promising new catalytic transformations; however, development in this field is still at an early stage compared to the state of the art in cross-coupling reactions using aryl and alkyl halides. This Review begins with a brief introduction of four extensively investigated modes of catalysis for forming C-C bonds from C-H bonds: Pd(II)/Pd(0), Pd(II)/Pd(IV), Pd(0)/Pd(II)/Pd(IV), and Pd(0)/Pd(II) catalysis. A more detailed discussion is then directed towards the recent development of palladium(II)-catalyzed coupling of C-H bonds with organometallic reagents through a Pd(II)/Pd(0) catalytic cycle. Despite the progress made to date, improving the versatility and practicality of this new reaction remains a tremendous challenge.

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          Author and article information

          Journal
          Angew. Chem. Int. Ed. Engl.
          Angewandte Chemie (International ed. in English)
          1521-3773
          1433-7851
          2009
          : 48
          : 28
          Affiliations
          [1 ] Chemical Development Department, Albany Molecular Research, Inc., 21 Corporate Circle, Albany, NY 12203, USA.
          Article
          NIHMS115817
          10.1002/anie.200806273
          2722958
          19557755
          b34c72b7-a4f5-4735-b2bc-fb72606a56b3

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