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Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.

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      Abstract

      In the past decade, palladium-catalyzed C-H activation/C-C bond-forming reactions have emerged as promising new catalytic transformations; however, development in this field is still at an early stage compared to the state of the art in cross-coupling reactions using aryl and alkyl halides. This Review begins with a brief introduction of four extensively investigated modes of catalysis for forming C-C bonds from C-H bonds: Pd(II)/Pd(0), Pd(II)/Pd(IV), Pd(0)/Pd(II)/Pd(IV), and Pd(0)/Pd(II) catalysis. A more detailed discussion is then directed towards the recent development of palladium(II)-catalyzed coupling of C-H bonds with organometallic reagents through a Pd(II)/Pd(0) catalytic cycle. Despite the progress made to date, improving the versatility and practicality of this new reaction remains a tremendous challenge.

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      Affiliations
      [1 ] Chemical Development Department, Albany Molecular Research, Inc., 21 Corporate Circle, Albany, NY 12203, USA.
      Journal
      Angew. Chem. Int. Ed. Engl.
      Angewandte Chemie (International ed. in English)
      1521-3773
      1433-7851
      2009
      : 48
      : 28
      19557755
      10.1002/anie.200806273
      2722958
      NIHMS115817

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