For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
6
views
27
references
 Top references
cited by
3
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      268
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      A nomogram for predicting left atrial thrombus or spontaneous echo contrast in non-valvular atrial fibrillation patients using hemodynamic parameters from transthoracic echocardiography

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with a high risk of stroke. This study was designed to investigate the relationship between hemodynamic parameters and left atrial thrombus/spontaneous echo contrast (LAT/SEC) in non-valvular atrial fibrillation (NVAF) patients and establish a predictive nomogram that integrates hemodynamic parameters with clinical predictors to predict the risk of LAT/SEC.

          Methods

          From January 2019 to September 2022, a total of 354 consecutive patients with NVAF were enrolled in this cross-sectional study at the First Affiliated Hospital of Guangxi Medical University. To identify the optimal predictive features, we employed least absolute shrinkage and selection operator (LASSO) regression. A multivariate logistic regression model was subsequently constructed, and the results were visualized with a nomogram. We evaluated the model's performance using discrimination, calibration, and the concordance index (C-index).

          Results

          We observed a 38.7% incidence of SEC/TH in NVAF patients. Independent influencing factors of LAT/SEC were identified through LASSO and multivariate logistic regression. Finally, four indicators were included, namely, previous stroke/transient ischaemic attack (OR = 4.25, 95% CI = 1.57–12.23, P = 0.006), left atrial volume index (LAVI) (OR = 1.04, 95% CI = 1.01–1.06, P = 0.001), S/D ratio (OR = 0.27, 95% CI = 0.11–0.59, P = 0.002), and left atrial acceleration factor (OR = 4.95, 95% CI = 2.05–12.79, P = 0.001). The nomogram, which incorporated these four influencing factors, demonstrated excellent predictive ability. The training set had a C-index of 0.878, while the validation set had a C-index of 0.872. Additionally, the calibration curve demonstrated great consistency between the predicted probabilities and the observed outcomes, and the decision curve analysis confirmed the important clinical advantage of the model for patients with NVAF.

          Conclusion

          Our findings indicate that an enlarged left atrium and abnormal hemodynamic parameters in the left atrial and pulmonary veins are linked to a greater risk of LAT/SEC. Previous stroke/transient ischaemic attack, LAVI, the S/D ratio, and left atrial acceleration factor were independently associated with LAT/SEC in NVAF patients. With the incorporation of these four variables, the developed nomogram effectively predicts the risk of LAT/SEC and outperforms the CHA 2DS 2-VASc score.

          Related collections

          Most cited references27

          • Record: found
          • Abstract: not found
          • Article: not found

          2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation

          Craig T. January, L Wann, Hugh Calkins … (2019)
          Article 0 comments Cited 819 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Biomarkers in atrial fibrillation: a clinical review.

            Jonas Oldgren, Ziad Hijazi, Lars Wallentin … (2013)
            Assessment of atrial fibrillation (AF)-associated stroke risk is at present mainly based on clinical risk scores such as CHADS2 and CHA2DS2-VASc, although these scores provide only modest discrimination of risk for individual patients. Biomarkers derived from the blood may help refine risk assessment in AF for stroke outcomes and for mortality. Recent studies of biomarkers in AF have shown that they can substantially improve risk stratification. Cardiac biomarkers, such as troponin and natriuretic peptides, significantly improve risk stratification in addition to current clinical risk stratification models. Similar findings have recently been described for markers of renal function, coagulation, and inflammation in AF populations based on large randomized prospective clinical trials or large community-based cohorts. These new findings may enable development of novel tools to improve clinical risk assessment in AF. Biomarkers in AF may also improve the understanding of the pathophysiology of AF further as well as potentially elucidate novel treatment targets. This review will highlight novel associations of biomarkers and outcomes in AF as well as recent progress in the use of biomarkers for risk stratification.
            Article 0 comments Cited 89 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Stroke in developing countries: can the epidemic be stopped and outcomes improved?

              Valery L Feigin (2007)
              Article 0 comments Cited 74 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Decai Zeng: URI : https://loop.frontiersin.org/people/2002561/overviewRole: Role: Role: Role: Role:
                Xiaofeng Zhang: URI : https://loop.frontiersin.org/people/1729390/overviewRole: Role: Role: Role: Role:
                Shuai Chang: Role: Role: Role:
                Yanfen Zhong: Role: Role: Role:
                Yongzhi Cai: URI : https://loop.frontiersin.org/people/2027871/overviewRole: Role: Role:
                Tongtong Huang: Role: Role: Role:
                Ji Wu: URI : https://loop.frontiersin.org/people/2002482/overviewRole: Role: Role: Role: Role:
                Journal
                Journal ID (nlm-ta): Front Cardiovasc Med
                Journal ID (iso-abbrev): Front Cardiovasc Med
                Journal ID (publisher-id): Front. Cardiovasc. Med.
                Title: Frontiers in Cardiovascular Medicine
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 2297-055X
                Publication date (Electronic): 08 February 2024
                Publication date Collection: 2024
                Volume: 11
                Electronic Location Identifier: 1337853
                Affiliations
                Department of Ultrasound, First Affiliated Hospital , Guangxi Medical University, Nanning, China
                Author notes

                Edited by: Alun Hughes, University College London, United Kingdom

                Reviewed by: Aneesh Dhore-patil, Houston Methodist Hospital, United States

                Sung Il Im, Kosin University, Republic of Korea

                Andrea Sonaglioni, San Giuseppe Hospital, Italy

                [* ] Correspondence: Ji Wu gxnnwuji@ 123456163.com
                Article
                DOI: 10.3389/fcvm.2024.1337853
                PMC ID: 10881747
                PubMed ID: 38390444
                SO-VID: b3557b44-8625-4e6b-86fb-91bce8c8e7bd
                Copyright © © 2024 Zeng, Zhang, Chang, Zhong, Cai, Huang and Wu.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 13 November 2023
                Date accepted : 31 January 2024
                Page count
                Figures: 6, Tables: 2, Equations: 0, References: 27, Pages: 0, Words: 0
                Funding
                The authors declare financial support was received for the research, authorship, and/or publication of this article.
                This research was funded by the Key Program of Guangxi Natural Science Foundation (grant no. 2022JJD140147), Youth Science Foundation of Guangxi Medical University (grant no. GXMUYSF201916) and the Guangxi medical “139” Project for Training High-Level Backbone Talents (grant no. G201903014).
                Categories
                Subject: Cardiovascular Medicine
                Subject: Original Research
                Custom metadata
                section-at-acceptance Cardiovascular Imaging

                Keywords: non-valvular atrial fibrillation,nomogram,spontaneous echo contrast (sec),thrombus,hemodynamic parameters
                Data availability:
                Keywords: non-valvular atrial fibrillation, nomogram, spontaneous echo contrast (sec), thrombus, hemodynamic parameters

                Comments

                Comment on this article

                scite_

                Similar content268

                See all similar

                Cited by3

                See all cited by

                Most referenced authors403

                See all reference authors