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      Simple Sari Cloth Filtration of Water Is Sustainable and Continues To Protect Villagers from Cholera in Matlab, Bangladesh

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          ABSTRACT

          A simple method for filtering water to reduce the incidence of cholera was tested in a field trial in Matlab, Bangladesh, and proved effective. A follow-up study was conducted 5 years later to determine whether the filtration method continued to be employed by villagers and its impact on the incidence of cholera. A total of 7,233 village women collecting water daily for their households in Bangladesh were selected from the same study population of the original field trial for interviewing. Analysis of the data showed that 31% of the women used a filter of which 60% used sari filters for household water. Results showed that sari filtration not only was accepted and sustained by the villagers and benefited them, including their neighbors not filtering water, in reducing the incidence of cholera, the latter being an unexpected benefit.

          IMPORTANCE

          A simple method for filtering pond and river water to reduce the incidence of cholera, field tested in Matlab, Bangladesh, proved effective in reducing the incidence of cholera by 48%. A follow-up study conducted 5 years later showed that 31% of the village women continued to filter water for their households, with both an expected and an unexpected benefit that filtration had both a direct and indirect effect in reducing cholera (chi-square statistic of 1,591.94; P = <0.0001). Results of the study showed that the practice of filtration not only was accepted and sustained by the villagers but also benefited those who filtered their water as well as neighbors not filtering water for household use in reducing the incidence of cholera.

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          Most cited references15

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          Interventions to improve water quality for preventing diarrhoea: systematic review and meta-analysis.

          To assess the effectiveness of interventions to improve the microbial quality of drinking water for preventing diarrhoea. Systematic review. Cochrane Infectious Diseases Group's trials register, CENTRAL, Medline, Embase, LILACS; hand searching; and correspondence with experts and relevant organisations. Randomised and quasirandomised controlled trials of interventions to improve the microbial quality of drinking water for preventing diarrhoea in adults and in children in settings with endemic disease. Allocation concealment, blinding, losses to follow-up, type of intervention, outcome measures, and measures of effect. Pooled effect estimates were calculated within the appropriate subgroups. 33 reports from 21 countries documenting 42 comparisons were included. Variations in design, setting, and type and point of intervention, and variations in defining, assessing, calculating, and reporting outcomes limited the comparability of study results and pooling of results by meta-analysis. In general, interventions to improve the microbial quality of drinking water are effective in preventing diarrhoea. Effectiveness was not conditioned on the presence of improved water supplies or sanitation in the study setting and was not enhanced by combining the intervention with instructions on basic hygiene, a water storage vessel, or improved sanitation or water supplies--other common environmental interventions intended to prevent diarrhoea. Interventions to improve water quality are generally effective for preventing diarrhoea in all ages and in under 5s. Significant heterogeneity among the trials suggests that the level of effectiveness may depend on a variety of conditions that research to date cannot fully explain.
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            Point of use household drinking water filtration: A practical, effective solution for providing sustained access to safe drinking water in the developing world.

            The lack of safe water creates a tremendous burden of diarrheal disease and other debilitating, life-threatening illnesses for people in the developing world. Point-of-use (POU) water treatment technology has emerged as an approach that empowers people and communities without access to safe water to improve water quality by treating it in the home. Several POU technologies are available, but, except for boiling, none have achieved sustained, large-scale use. Sustained use is essential if household water treatment technology (HWT) is to provide continued protection, but it is difficult to achieve. The most effective, widely promoted and used POU HWTs are critically examined according to specified criteria for performance and sustainability. Ceramic and biosand household water filters are identified as most effective according to the evaluation criteria applied and as having the greatest potential to become widely used and sustainable for improving household water quality to reduce waterborne disease and death.
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              Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis.

              Decisions about the use of killed oral cholera vaccines, which confer moderate levels of direct protection to vaccinees, can depend on whether the vaccines also provide indirect (herd) protection when high levels of vaccine coverage are attained. We reanalysed data from a field trial in Bangladesh to ascertain whether there is evidence of indirect protection from killed oral cholera vaccines. We analysed the first year of surveillance data from a placebo-controlled trial of B subunit-killed whole-cell and killed whole-cell-only oral cholera vaccines in children and adult women in Bangladesh. We calculated whether there was an inverse, monotonic trend for the relation between the level of vaccine coverage in a residential cluster and the incidence of cholera in individual vaccine recipients or placebo recipients residing in the cluster after controlling for potential confounding variables. Vaccine coverage of the targeted population ranged from 4% to 65%. Incidence rates of cholera among placebo recipients were inversely related to levels of vaccine coverage (7.01 cases per 1000 in the lowest quintile of coverage vs 1.47 cases per 1000 in the highest quintile; p<0.0001 for trend). Receipt of vaccine by an individual and the level of vaccine coverage of the individual's cluster were independently related to a reduced risk of cholera. Moreover, after adjustment for the level of vaccine coverage of the cluster, vaccine protective efficacy remained significant (55% [95% CI 41-66], p<0.0001). In addition to providing direct protection to vaccine recipients, killed oral cholera vaccines confer significant herd protection to neighbouring non-vaccinated individuals. Use of these vaccines could have a major effect on the burden of cholera in endemic settings.
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                Author and article information

                Journal
                mBio
                MBio
                mbio
                mbio
                mBio
                mBio
                American Society of Microbiology (1752 N St., N.W., Washington, DC )
                2150-7511
                18 May 2010
                April 2010
                : 1
                : 1
                : e00034-10
                Affiliations
                Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA [ a ];
                International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh [ b ];
                Department of Geography, University of North Carolina, Chapel Hill, North Carolina, USA [ c ];
                Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA [ d ];
                Johns Hopkins School of Public Health, Baltimore, Maryland, USA [ e ]; and
                Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA [ f ]
                Author notes
                Address correspondence to Rita R. Colwell, rcolwell@ 123456umiacs.umd.edu .
                [*]

                Present address: Estelle Russek-Cohen, Diagnostics Branch, Division of Biostatistics, Office of Surveillance and Biometrics, U.S. Food and Drug Administration, Rockville, Maryland, USA; G. Balakrish Nair, National Institute of Cholera and Enteric Diseases, P-33, Cit Scheme XM, Beliaghata, Kolkata, India.

                Invited Editor Christine Moe, Emory University

                Editor Keith Klugman, Emory University

                Article
                mBio00034-10
                10.1128/mBio.00034-10
                2912662
                20689750
                b373d122-1a9e-45ee-a0bf-29cadf1797b1
                Copyright © 2010 Huq et al.

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 25 February 2010
                : 22 April 2010
                Categories
                Research Article

                Life sciences
                Life sciences

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