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      Licorice and its active compound glycyrrhizic acid ameliorates cisplatin-induced nephrotoxicity through inactivation of p53 by scavenging ROS and overexpression of p21 in human renal proximal tubular epithelial cells.

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          Abstract

          Nephrotoxicity is one of the major side effects that limit the use of cisplatin in cancer therapy. Cisplatin-induced apoptosis in renal cells is associated with reactive oxygen species (ROS)-mediated p53 activation. Licorice (Glycyrrhiza uralensis Fischer) is one of the most widely used medicinal herbs in Korea, China and Japan. The aim of the study was to evaluate the protective effects of licorice extract (LE) and its active compound glycyrrhizic acid (GA) against cisplatin-induced nephrotoxicity in human renal proximal tubular epithelial (HK-2) cells.

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          Author and article information

          Journal
          Eur Rev Med Pharmacol Sci
          European review for medical and pharmacological sciences
          2284-0729
          1128-3602
          February 2017
          : 21
          : 4
          Affiliations
          [1 ] Department of Pathology, College of Korean Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea. omdjbh@wku.ac.kr.
          Article
          28272690

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