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      Early surgical debridement in the management of infectious scleritis after pterygium excision

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          Abstract

          Purpose

          The purpose of this study was to report outcomes of infectious scleritis after pterygium surgery, managed with antibiotic therapies and early scleral debridement.

          Methods

          Retrospective chart review of 13 consecutive cases of infectious scleritis after pterygium excision between 1999 and 2009 was conducted. Collected data included prior medical and surgical history, latency period between pterygium surgery and presentation of infectious scleritis, culture and histopathologic findings, antibiotic regimen, length of hospital stay, visual acuity before and after treatment, and complications.

          Results

          Median follow-up was at 14 months. Twelve patients underwent prompt surgical debridement after infectious scleritis diagnosis (median, 2.5 days). Debridement was delayed in one patient. Median hospital stay was 3 days. Best-corrected visual acuity improved in ten patients, remained stable in one patient, and decreased in two patients following treatment. Complications included scleral thinning requiring scleral patch graft (1/13), glaucoma (3/13), and progression to phthisis bulbi (1/13). No patients required enucleation.

          Conclusions

          In contrast to the generally poor outcomes in the literature, early surgical debridement of pterygium-associated infectious scleritis appears to offer improved prognosis.

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          Most cited references20

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          Microbial biofilms.

          Direct observations have clearly shown that biofilm bacteria predominate, numerically and metabolically, in virtually all nutrient-sufficient ecosystems. Therefore, these sessile organisms predominate in most of the environmental, industrial, and medical problems and processes of interest to microbiologists. If biofilm bacteria were simply planktonic cells that had adhered to a surface, this revelation would be unimportant, but they are demonstrably and profoundly different. We first noted that biofilm cells are at least 500 times more resistant to antibacterial agents. Now we have discovered that adhesion triggers the expression of a sigma factor that derepresses a large number of genes so that biofilm cells are clearly phenotypically distinct from their planktonic counterparts. Each biofilm bacterium lives in a customized microniche in a complex microbial community that has primitive homeostasis, a primitive circulatory system, and metabolic cooperativity, and each of these sessile cells reacts to its special environment so that it differs fundamentally from a planktonic cell of the same species.
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            Bacterial Biofilms: A Common Cause of Persistent Infections

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              Tobramycin resistance of Pseudomonas aeruginosa cells growing as a biofilm on urinary catheter material.

              When disks of urinary catheter material were exposed to the flow of artificial urine containing cells of Pseudomonas aeruginosa, a thick adherent biofilm, composed of these bacteria and of their exopolysaccharide products, developed on the latex surface within 8 h. After this colonization, sterile artificial urine containing 1,000 micrograms of tobramycin per ml was flowed past this established biofilm, and a significant proportion of the bacterial cells within the biofilm were found to be still viable after 12 h of exposure to this very high concentration of aminoglycoside antibiotic. Planktonic (floating) cells taken from the test system just before the exposure of the biofilm to the antibiotic were completely killed by 50 micrograms of tobramycin per ml. The MIC of tobramycin for cells taken from the seeding cultures before colonization of the catheter material, and for surviving cells recovered directly from the tobramycin-treated biofilm, was found to be 0.4 micrograms/ml when dispersed cells were assayed by standard methods. These data indicate that growth within thick adherent biofilms confers a measure of tobramycin resistance on cells of P. aeruginosa.
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                Author and article information

                Contributors
                +1-443-2877923 , syiu2@jhmi.edu
                Journal
                J Ophthalmic Inflamm Infect
                J Ophthalmic Inflamm Infect
                Journal of Ophthalmic Inflammation and Infection
                Springer-Verlag (Berlin/Heidelberg )
                1869-5760
                22 February 2012
                22 February 2012
                June 2012
                : 2
                : 2
                : 81-87
                Affiliations
                [1 ]Keck School of Medicine, University of Southern California, Los Angeles, CA USA
                [2 ]Doheny Eye Institute, Los Angeles, CA USA
                [3 ]Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University, 400 N Broadway/Smith Bldg 6001-R, Baltimore, MD 21231 USA
                Article
                62
                10.1007/s12348-012-0062-1
                3345049
                22354483
                b37c7ac9-27fc-4955-b7ec-c3822b0120bd
                © The Author(s) 2012
                History
                : 11 August 2011
                : 31 January 2012
                Categories
                Original Research
                Custom metadata
                © Springer-Verlag 2012

                Ophthalmology & Optometry
                infectious scleritis,biofilm,ophthalmology,pterygium excision,surgical debridement,medicine & public health

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