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      VEGF-targeted therapy: mechanisms of anti-tumour activity.

      1 ,
      Nature reviews. Cancer
      Springer Science and Business Media LLC

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          Abstract

          Several vascular endothelial growth factor (VEGF)-targeted agents, administered either as single agents or in combination with chemotherapy, have been shown to benefit patients with advanced-stage malignancies. VEGF-targeted therapies were initially developed with the notion that they would inhibit new blood vessel growth and thus starve tumours of necessary oxygen and nutrients. It has become increasingly apparent, however, that the therapeutic benefit associated with VEGF-targeted therapy is complex, and probably involves multiple mechanisms. A better understanding of these mechanisms will lead to future advances in the use of these agents in the clinic.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-1768
          1474-175X
          Aug 2008
          : 8
          : 8
          Affiliations
          [1 ] Department of Surgical Oncology, Unit 444, University of Texas M.D. Anderson Cancer Center, PO Box 301402, Houston, Texas 77230-1402, USA. lellis@mdanderson.org
          Article
          nrc2403
          10.1038/nrc2403
          18596824
          b37e2094-1405-4720-a126-f58e24c8a750
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