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      Reduced myocardial 123-iodine metaiodobenzylguanidine uptake: a prognostic marker in familial amyloid polyneuropathy.

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          Abstract

          Transthyretin familial amyloid polyneuropathy is a hereditary form of amyloidosis characterized by sensorimotor and autonomic neuropathy, cardiac conduction defects, and infiltrative cardiomyopathy. Previous studies have suggested that myocardial sympathetic denervation assessed by 123-iodine metaiodobenzylguanidine (MIBG) imaging occurs early in disease progression. However, its prognostic significance was never evaluated. We aimed to study the long-term prognostic value of myocardial sympathetic denervation detected by MIBG imaging in transthyretin familial amyloid polyneuropathy.

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          Author and article information

          Journal
          Circ Cardiovasc Imaging
          Circulation. Cardiovascular imaging
          Ovid Technologies (Wolters Kluwer Health)
          1942-0080
          1941-9651
          Sep 2013
          : 6
          : 5
          Affiliations
          [1 ] Departments of Cardiology and Neurosciences, Santa Maria University Hospital, Lisbon, Portugal; University Clinic of Cardiology, Translational Clinical Physiology Unit, Instituto de Medicina Molecular, and Institute of Nuclear Medicine, Lisbon Medical School, University of Lisbon, Portugal; and Programme for Advanced Medical Education, Lisbon, Portugal.
          Article
          CIRCIMAGING.112.000367
          10.1161/CIRCIMAGING.112.000367
          23833285
          b383ed69-8352-46c8-96ec-46e332cb7cf7

          radionuclide imaging, amyloid, prognosis

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