Maria C Azevedo Coutinho 1 , Nuno Cortez-Dias , Guilhermina Cantinho , Isabel Conceição , António Oliveira , Armando Bordalo e Sá , Susana Gonçalves , Ana G Almeida , Mamede de Carvalho , António Nunes Diogo
Transthyretin familial amyloid polyneuropathy is a hereditary form of amyloidosis characterized by sensorimotor and autonomic neuropathy, cardiac conduction defects, and infiltrative cardiomyopathy. Previous studies have suggested that myocardial sympathetic denervation assessed by 123-iodine metaiodobenzylguanidine (MIBG) imaging occurs early in disease progression. However, its prognostic significance was never evaluated. We aimed to study the long-term prognostic value of myocardial sympathetic denervation detected by MIBG imaging in transthyretin familial amyloid polyneuropathy.