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Assamicin I and II, Novel Triterpenoid Saponins with Insulin-Like Activity from Aesculus assamica Griff.
Takashi Sakurai ,
Toshio Nishimura ,
Noboru Otake ,
Yao Xinsheng ,
Keiichi Abe ,
Mitsuhiro Zeida ,
Hiromichi Nagasawa ,
Shohei Sakuda
March 2002
March 2002
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Abstract
Two novel triterpenoid saponins with insulin-like activity, termed assamicin I and
II, were isolated from the roots of Aesculus assamica Griff. and their structures
were characterized as 1 and 2, respectively. They inhibited release of free fatty
acids from epinephrine-treated rat adipocytes and enhanced glucose uptake into 3T3-L1
adipocytes.