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      Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin

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          Abstract

          Ferulic acid is a potent ubiquitous plant antioxidant. Its incorporation into a topical solution of 15%l-ascorbic acid and 1%alpha-tocopherol improved chemical stability of the vitamins (C+E) and doubled photoprotection to solar-simulated irradiation of skin from 4-fold to approximately 8-fold as measured by both erythema and sunburn cell formation. Inhibition of apoptosis was associated with reduced induction of caspase-3 and caspase-7. This antioxidant formulation efficiently reduced thymine dimer formation. This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer.

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          Author and article information

          Journal
          Journal of Investigative Dermatology
          Journal of Investigative Dermatology
          Wiley
          0022202X
          October 2005
          October 2005
          : 125
          : 4
          : 826-832
          Article
          10.1111/j.0022-202X.2005.23768.x
          16185284
          b3b13d2f-b909-4621-b5fb-cbea5efb7a06
          © 2005

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/


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