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      New culture devices in ART.

      1 , ,
      Placenta
      Elsevier BV

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          Abstract

          During the past decades, improvements in culture of preimplantation embryos have contributed substantially in the success of human assisted reproductive techniques. However, most efforts were focused on optimization of media and gas components, while the established physical conditions and applied devices have remained essentially unchanged. Very recently, however, intensive research has been started to provide a more appropriate environment for the embryos and to replace the rather primitive and inappropriate devices with more sophisticated and practical instruments. Success has been reported with simple or sophisticated tools (microwells or microchannels) that allow accumulation of autocrine factors and establishment of a proper microenvironment for embryos cultured individually or in groups. The microchannel system may also offer certain level of automation and increased standardization of culture parameters. Continuous monitoring of individual embryos by optical or biochemical methods may help to determine the optimal day of transfer, and selection of the embryo with highest developmental competence for transfer. This advancement may eventually lead to adjustment of the culture environment to each individual embryo according to its actual needs. Connection of these techniques to additional radical approaches as automated ICSI or an ultimate assisted hatching with full removal of the zona pellucida after or even before fertilization may result in devices with high reliability and consistency, to increase the overall efficiency and decrease the work-intensity, and to eliminate the existing technological gap between laboratory embryology work and most other fields of biomedical sciences.

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          Author and article information

          Journal
          Placenta
          Placenta
          Elsevier BV
          1532-3102
          0143-4004
          Sep 2011
          : 32 Suppl 3
          Affiliations
          [1 ] G.EN.E.R.A. Centre for Reproductive Medicine, Clinica Valle Giulia, Via G. De Notaris 2b, 00197 Rome, Italy. rienzi@generaroma.it
          Article
          S0143-4004(11)00239-6
          10.1016/j.placenta.2011.06.018
          21764448
          b3bbb16e-2944-4c88-892c-7d698f7bf9e4
          Copyright © 2011 Elsevier Ltd. All rights reserved.
          History

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