Infection Status and Influencing Factors of Human Papillomavirus in Patients with Condylomata Acuminata

Abstract

Objective: To study the infection status of human papillomavirus (HPV) in patients with condylomata acuminata (CA) in mainland China and explore its influencing factors.

Methods: The literatures on HPV detection of CA patients in mainland China published between January 1990 and December 2013 were systematically retrieved from PubMed, Science Direct Online, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, and the VIP database. According to the sample size, HPV infection rates of each literature were weighted and combined and the infection rates of HPV and the combined infection rate of each genotype of CA patients were calculated, and the combined infection rate of HPV of CA patients in different years and areas of study was analyzed. Multivariate Logistic regression analysis was used to investigate the influencing factors of CA patients infected/detected with HPV.

Results: A total of 67 literatures were included in the study. The number of CA patients accumulated to 10 757, and 9 328 cases (86.7%) infected with HPV. The combined infection rate of HPV in patients with CA was 95.7% (95% CI (95.2%, 96.2%)), and the top three genotypes with high infection rate were HPV6/11 (81.2%, 95% CI (77.1%, 85.2%)), HPV6 (43.8%, 95% CI (35.2%, 52.5%)), HPV11 (38.3%, 95% CI (32.8%, 43.8%)). The combined infection rate of HPV in patients with CA between 1990 and 2003 and between 2004 and 2013 was 96.6% (95% CI (95.8%, 97.5%)) and 94.6% (95% CI (94.0%, 95.3%)) respectively; the combined infection rate of HPV of patients in eastern, middle and western areas was 95.1% (95% CI (94.4%, 95.7%)), 91.7% (95% CI (89.3%, 94.1%)), and 96.5% (95% CI (95.4%, 97.6%)) respectively. Multivariate Logistic regression analysis showed that the year of study, areas of study, type of specimen and methods of diagnosis significantly influenced the infection and detection of HPV in CA patients (P ＜ 0.05). After analyzing different genotypes, the results showed that the year of study, areas of study, types of specimen, and methods of diagnosis were influencing factors for CA patients infected/detected with HPV6, the year of study, western studied area, types of specimen, and methods of diagnosis were influencing factors for CA patients infected/detected with HPV11, the middle studied area and types of specimen were influencing factors for CA patients infected/detected with HPV16, and the areas of study, types of specimen and methods of diagnosis were influencing factors for CA patients infected/detected with HPV18 (P ＜ 0.05).

Conclusion: HPV6 and HPV11 genotypes are the main types of HPV infection in patients with CA in mainland China. The infection rate has declined in the past 10 years, relatively high rate of infection is found in the eastern region. Definite diagnosis by pathological examination and the use of exfoliated cells for DNA detection can improve the detection rate of HPV in patients with CA.