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Abstract
Weight change over a 1-year period was examined in a highly homogeneous group of 78,694
women ages 50-69 enrolled in a prospective mortality study. Artificial sweetener usage
increased with relative weight and decreased with age. Users were significantly more
likely than nonusers to gain weight, regardless of initial weight. Average weight
gains or losses by artificial sweetener users differed by less than 2 pounds from
gains or losses among nonusers. These results were not explicable by differences in
food consumption patterns. The data do not support the hypothesis that long-term artificial
sweetener use either helps weight loss or prevents weight gain.