31
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Calorie restriction and NAD⁺/sirtuin counteract the hallmarks of aging.

      1
      Frontiers in bioscience (Landmark edition)

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Among diverse environmental factors that modify aging, diet has a profound effect. Calorie restriction (CR), which entails reduced calorie consumption without malnutrition, is the only natural regimen shown to extend maximum and mean lifespan, as well as healthspan in a wide range of organisms. Although the knowledge about the biological mechanisms underlying CR is still incipient, various approaches in biogerontology research suggest that CR can ameliorate hallmarks of aging at the cellular level including telomere erosion, epigenetic alterations, stem cells depletion, cellular senescence, mitochondrial dysfunction, genomic instability, proteostasis imbalance, impaired nutrient sensing and abnormal intercellular communication. Currently, the NAD + /sirtuin pathway is one of the few mechanisms described to mediate CR effects and sirtuin-activating compounds (STACs) mimic many effects of CR. Herein, we discuss the effects of CR on healthspan with emphasis on neuroprotection, how CR counteracts cellular aging, how sirtuin pathways intertwine with CR, and the relevance of STACs in mimicking CR effects.

          Related collections

          Author and article information

          Journal
          Front Biosci (Landmark Ed)
          Frontiers in bioscience (Landmark edition)
          1093-4715
          1093-4715
          Jun 01 2014
          : 19
          Affiliations
          [1 ] Instituto Nacional de Geriatria, Institutos Nacionales de Salud, D. F., Mexico.
          Article
          4283
          10.2741/4283
          24896352
          b3eb4257-d5ab-4041-a5c8-44eddce39f5f
          History

          Comments

          Comment on this article