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      Short Stature with Normal Growth Hormone Stimulation Testing: Lack of Evidence for Partial Growth Hormone Deficiency or Insensitivity

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          Objectives: To test the hypothesis that children with short stature and peak stimulated GH (pGH) of 7–10 µg/l have partial GH deficiency and to test the hypothesis that short children with normal pGH but low IGF-I levels have partial GH deficiency or partial GH insensitivity. Design and Patients: Retrospective analysis of the clinical and biochemical profiles of 76 children who underwent an evaluation for short stature (height <5th percentile) that included two, sex steroid-primed GH stimulation tests. Results: Patients with pGH <7 µg/l (n = 14) differed significantly from those with pGH >7 µg/l (n = 62), having greater midparental height (MPH) SDS, a greater disparity between height SDS and MPH SDS, and lower IGF-I SDS. Patients with pGH of 7–10 µg/l (n = 12) did not have characteristics intermediate between those with pGH <7 µg/l and those with pGH ≧10 µg/l, but instead resembled those with pGH ≧10 µg/l. Patients with pGH ≧7 µg/l, but low IGF-I (<–2 SDS) (n = 5), did not show characteristics intermediate between those with pGH <7 µg/l and those with pGH ≧7 µg/l and normal IGF-I. Conclusions: These data do not support either the hypothesis that children with pGH of 7–10 µg/l have partial GH deficiency or the hypothesis that children with normal pGH but subnormal IGF-I levels have partial GH deficiency or insensitivity.

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          A dominant-negative mutation of the growth hormone receptor causes familial short stature.


            Author and article information

            Horm Res Paediatr
            Hormone Research in Paediatrics
            S. Karger AG
            September 2004
            13 September 2004
            : 62
            : 2
            : 97-102
            Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., USA
            79711 Horm Res 2004;62:97–102
            © 2004 S. Karger AG, Basel

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            Page count
            Figures: 2, Tables: 1, References: 30, Pages: 6
            Original Paper


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