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      Short Stature with Normal Growth Hormone Stimulation Testing: Lack of Evidence for Partial Growth Hormone Deficiency or Insensitivity

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          Abstract

          Objectives: To test the hypothesis that children with short stature and peak stimulated GH (pGH) of 7–10 µg/l have partial GH deficiency and to test the hypothesis that short children with normal pGH but low IGF-I levels have partial GH deficiency or partial GH insensitivity. Design and Patients: Retrospective analysis of the clinical and biochemical profiles of 76 children who underwent an evaluation for short stature (height <5th percentile) that included two, sex steroid-primed GH stimulation tests. Results: Patients with pGH <7 µg/l (n = 14) differed significantly from those with pGH >7 µg/l (n = 62), having greater midparental height (MPH) SDS, a greater disparity between height SDS and MPH SDS, and lower IGF-I SDS. Patients with pGH of 7–10 µg/l (n = 12) did not have characteristics intermediate between those with pGH <7 µg/l and those with pGH ≧10 µg/l, but instead resembled those with pGH ≧10 µg/l. Patients with pGH ≧7 µg/l, but low IGF-I (<–2 SDS) (n = 5), did not show characteristics intermediate between those with pGH <7 µg/l and those with pGH ≧7 µg/l and normal IGF-I. Conclusions: These data do not support either the hypothesis that children with pGH of 7–10 µg/l have partial GH deficiency or the hypothesis that children with normal pGH but subnormal IGF-I levels have partial GH deficiency or insensitivity.

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          A dominant-negative mutation of the growth hormone receptor causes familial short stature.

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            Author and article information

            Journal
            HRE
            Horm Res Paediatr
            10.1159/issn.1663-2818
            Hormone Research in Paediatrics
            S. Karger AG
            1663-2818
            1663-2826
            2004
            September 2004
            13 September 2004
            : 62
            : 2
            : 97-102
            Affiliations
            Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., USA
            Article
            79711 Horm Res 2004;62:97–102
            10.1159/000079711
            15256821
            © 2004 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 2, Tables: 1, References: 30, Pages: 6
            Categories
            Original Paper

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