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      Primary Gleason pattern upgrading in contemporary patients with D'Amico low-risk prostate cancer: implications for future biomarkers and imaging modalities.

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          Abstract

          To retrospectively assess the rate of high-grade primary Gleason upgrading (HGPGU) to primary Gleason pattern 4 or 5 in a contemporary cohort of patients with D'Amico low-risk prostate cancer including those who fulfilled Prostate Cancer Research International Active Surveillance (PRIAS) criteria, and to develop a tool for HGPGU prediction. HGPGU is a contraindication in most active surveillance (AS) and focal therapy protocols.

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          Author and article information

          Journal
          BJU Int.
          BJU international
          Wiley-Blackwell
          1464-410X
          1464-4096
          May 2017
          : 119
          : 5
          Affiliations
          [1 ] Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC, Canada.
          [2 ] Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany.
          [3 ] Department of Urology, University of Montreal Health Center, Montreal, QC, Canada.
          [4 ] Department of Urology and Division of Experimental Oncology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
          [5 ] Department of Urology, Academic Hospital Braunschweig, Braunschweig, Germany.
          [6 ] Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
          Article
          10.1111/bju.13570
          27367469
          b425a060-9b68-4f14-be31-f261cc075ae4
          History

          PRIAS,active surveillance,genetic markers,multiparametric MRI,nomogram

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