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      Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline.

      Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org, Practice Committee of the American Society for Reproductive Medicine

      Fertility and sterility

      Elsevier BV

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          Abstract

          Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS. There is fair evidence that metformin alone does not increase rates of miscarriage when stopped at the initiation of pregnancy and insufficient evidence that metformin in combination with other agents used to induce ovulation increases live-birth rates.

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          Author and article information

          Journal
          Fertil. Steril.
          Fertility and sterility
          Elsevier BV
          1556-5653
          0015-0282
          September 2017
          : 108
          : 3
          Affiliations
          [1 ] American Society for Reproductive Medicine, Birmingham, Alabama.
          Article
          S0015-0282(17)30485-5
          10.1016/j.fertnstert.2017.06.026
          28865539

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