Blog
About

6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Predictors of thrombus formation after percutaneous left atrial appendage closure using the WATCHMAN device.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Percutaneous left atrial appendage (LAA) closure using the WATCHMAN device is a novel option for prevention of stroke associated with atrial fibrillation. However, device-related thrombus (DRT) formation is a concern after WATCHMAN implantation and the predictors of DRT still remain unclear. We aimed to clarify the predictors of DRT after WATCHMAN implantation by analyzing 78 patients (50 males, 72 ± 8 years, average CHA2DS2-VASc score of 4.3 + 1.8) who had undergone WATCHMAN implantation. WATCHMAN was successfully implanted in all patients and four (5%) developed DRT. Patients with DRT were more often female (75 vs. 34%, p = 0.094). CHA2DS2-VASc score was higher for patients with DRT (6.3 ± 2.5 vs. 4.2 ± 1.7, p = 0.022). Chronic kidney disease (100% vs. 43%, p = 0.024) and deep implantation of the device, which was defined as implant position below the LAA ostial plane (75 vs. 24%, p = 0.026), were more common in patients with DRT. HAS-BLED score (4.5 ± 1.0 vs. 3.5 ± 1.1, p = 0.074) was higher and oral anticoagulants (50 vs. 84%, p = 0.086) were less commonly prescribed for patients with DRT. Multivariable logistic regression analysis showed that higher CHA2DS2-VASc score (p = 0.022, OR 2.8) and deep implantation (p = 0.032, OR 24.7) were associated with DRT. These results suggest the possible role of CHA2S2-VASc scores and implantation depth in the development of DRT after percutaneous LAA closure using the WATCHMAN device.

          Related collections

          Author and article information

          Journal
          Heart Vessels
          Heart and vessels
          Springer Nature
          1615-2573
          0910-8327
          May 05 2017
          Affiliations
          [1 ] Department of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321, Bernau, Germany.
          [2 ] Department of Cardiology, Medical School Brandenburg, Ladeburger Straße 17, 16321, Bernau, Germany.
          [3 ] Department of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321, Bernau, Germany. c.butter@immanuel.de.
          [4 ] Department of Cardiology, Medical School Brandenburg, Ladeburger Straße 17, 16321, Bernau, Germany. c.butter@immanuel.de.
          Article
          10.1007/s00380-017-0971-x
          10.1007/s00380-017-0971-x
          28477098

          Comments

          Comment on this article