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      Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Salvia verbenaca L. : A Review

      Biointerface Research in Applied Chemistry
      AMG Transcend Association

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          Abstract

          Salvia verbenaca L. is a Mediterranean medicinal plant used traditionally to treat several diseases such as burns, ocular wounds, contusion, stomach pain, eye diseases, dermal inflammation. This review highlighted previous reports, including the botanical, taxonomical, geographical distribution, traditional use, phytochemical, biological, and toxicological effects of S. verbenaca. The data were gathered from scientific databases PubMed, Scopus, Web of Science, Google Scholar, ScienceDirect, SpringerLink. The presented data on S. verbenaca were organized according to ethnomedicinal use, bioactive compounds, pharmacology, and toxicological investigation. Ethnobotanical studies reported that many folk medicines use S. verbenaca, especially against wounds, burns, and cicatrization. The phytochemical compounds in different parts of S. verbenaca belonged to different classes of chemical compounds, including terpenoids, flavonoids, phenolic acids, phenolic diterpenoids, and fatty acids. The extracts and essential oils from S. verbenaca have a wide variety of in vitro and in vivo pharmacological activities, i.e., antioxidant, antifungal, antidiabetic, anti-inflammatory, antitumor, antihemolytic, antihypertensive, antileishmanial, and immunomodulatory activities. This research suggests that the biological activities of S. verbenaca prove its traditional uses. However, in-depth investigations are required, such as pharmacokinetic, pharmacodynamic, and toxicological experiments, to prove the efficacy and safety of S. verbenaca extracts and essential oils and their bioactive compounds.

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          Author and article information

          Journal
          Biointerface Research in Applied Chemistry
          Biointerface Res Appl Chem
          AMG Transcend Association
          2069-5837
          June 24 2021
          June 21 2021
          : 12
          : 2
          : 1437-1469
          Article
          10.33263/BRIAC122.14371469
          b440ff37-ccd2-467f-8296-7926e8871235
          © 2021
          History

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