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      Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer.

      Nature
      Amino Acid Sequence, Animals, Base Sequence, Blastomeres, transplantation, Cell Polarity, DNA Primers, DNA, Complementary, Digestive System, embryology, Embryonic Induction, physiology, radiation effects, Endoderm, Gastrula, Head, In Situ Hybridization, Intercellular Signaling Peptides and Proteins, Mesoderm, Molecular Sequence Data, Proteins, genetics, secretion, RNA, Messenger, metabolism, Tail, Ultraviolet Rays, Xenopus, Xenopus Proteins

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          Abstract

          An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.

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