Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia.

Abstract

Phytochemical investigation of the fruits of Momordica charantia resulted in the isolation and characterization of two new (1 and 2) and eight known cucurbitane-type triterpene glycosides and one cucurbitane-type triterpene. The glycosides (7beta,25-dimethoxycucurbita-5(6),23( E)-dien-19-al 3- O-beta-D-allopyranoside (1); 25-methoxycucurbita-5(6),23(E)-dien-19-ol 3-O-beta-D-allopyranoside (2); momordicosides A, F (1), F (2), G, K, and L; and goyaglycoside-c and goyaglycoside-d) and the triterpene [3 beta,7 beta,25-trihydroxycucurbita-5,23(E)-dien-19-al] were characterized by physical, chemical, and spectroscopic techniques, including 1D- and 2D-NMR as well as by comparison with the reported data.