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      Atriopeptins are potent inhibitors of ACTH secretion by rat anterior pituitary cells in vitro: involvement of the atrial natriuretic factor receptor domain of membrane-bound guanylyl cyclase.

      1 ,
      The Journal of endocrinology
      Bioscientifica

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          Abstract

          The current concept of the regulation of adenohypophysial corticotrophin secretion assigns a stimulatory role to neuropeptides of hypothalamic origin and an inhibitory function to adrenocortical glucocorticoid hormones. It has been shown that in isolated perifused rat anterior pituitary cells atriopeptins (1-28) and (5-28), but not (5-25), potently suppress corticotrophin secretion elicited by 41-residue corticotrophin-releasing factor and arginine vasopressin. The action of atriopeptins is associated with a marked increase in the cellular content of cyclic GMP. Moreover, 8-Br-cyclic GMP, a cell membrane permeant analogue of cyclic GMP, also inhibited secretagogue-stimulated corticotrophin release. It is suggested that atrio-peptins of hypothalamic and perhaps of cardiac origin may be functionally significant corticotrophin-release inhibiting factors.

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          Author and article information

          Journal
          J Endocrinol
          The Journal of endocrinology
          Bioscientifica
          0022-0795
          0022-0795
          Apr 1990
          : 125
          : 1
          Affiliations
          [1 ] Department of Human Anatomy, University of Oxford.
          Article
          10.1677/joe.0.1250039
          1971004
          b47cd0ae-5392-43f9-8850-7077c35bad4e
          History

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