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      Outer membrane permeability and antibiotic resistance

      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

      Elsevier BV

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          Abstract

          To date most antibiotics are targeted at intracellular processes, and must be able to penetrate the bacterial cell envelope. In particular, the outer membrane of gram-negative bacteria provides a formidable barrier that must be overcome. There are essentially two pathways that antibiotics can take through the outer membrane: a lipid-mediated pathway for hydrophobic antibiotics, and general diffusion porins for hydrophilic antibiotics. The lipid and protein compositions of the outer membrane have a strong impact on the sensitivity of bacteria to many types of antibiotics, and drug resistance involving modifications of these macromolecules is common. This review will describe the molecular mechanisms for permeation of antibiotics through the outer membrane, and the strategies that bacteria have deployed to resist antibiotics by modifications of these pathways.

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          Author and article information

          Journal
          Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
          Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
          Elsevier BV
          15709639
          May 2009
          May 2009
          : 1794
          : 5
          : 808-816
          Article
          10.1016/j.bbapap.2008.11.005
          2696358
          19100346
          © 2009

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