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Arginine is a physiological precursor of endothelium-derived nitric oxide
Harald H.H.W. Schmidt ,
Heinz Nau ,
Werner Wittfoht ,
Jörg Gerlach ,
Karl-Ernst Prescher ,
Marcus M. Klein ,
Feraydoon Niroomand ,
Eycke Böhme
September 1988
September 1988
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Abstract
ATP dose dependently stimulated the formation and release of nitric oxide (NO) from
perfused rabbit aorta. L-Canavanine, an inhibitor of various L-arginine-utilizing
enzymes, abolished basal and ATP-induced NO formation and release. ATP increased the
accumulation of presumably NO-derived NO2- in the medium of primary cultures of bovine
aortic endothelial cells. 15NO, 15NO2- and 15NO3- formation was found when L-[guanido-15N2]arginine
was added to the culture medium. We conclude that the terminal guanidino nitrogens
of L-arginine are the physiological precursors of endothelium-derived NO.