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Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans.
Samir Jaber
1 ,
Basil J Petrof ,
Boris Jung ,
Gérald Chanques ,
Jean-Philippe Berthet ,
Christophe Rabuel ,
Hassan Bouyabrine ,
Patricia Courouble ,
Christelle Koechlin-Ramonatxo ,
Mustapha Sebbane ,
Thomas Similowski ,
Valérie Scheuermann ,
Alexandre Mebazaa ,
Xavier Capdevila ,
Dominique Mornet ,
Jacques Mercier ,
Alain Lacampagne ,
Alexandre Philips ,
Stefan Matecki
Feb 01 2011
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Abstract
Diaphragmatic function is a major determinant of the ability to successfully wean patients from mechanical ventilation (MV). Paradoxically, MV itself results in a rapid loss of diaphragmatic strength in animals. However, very little is known about the time course or mechanistic basis for such a phenomenon in humans.