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      Pregabalin and Speech Pathology Combination Therapy for Refractory Chronic Cough: A Randomized Controlled Trial.

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          Abstract

          Chronic refractory cough (CRC) is a difficult problem to treat. Speech pathology treatment (SPT) improves symptoms but resolution is incomplete. Centrally acting neuromodulators also improve cough symptoms, but not cough reflex sensitivity, and the effect is short-lived. We hypothesized that combined SPT and centrally acting neuromodulators would have a superior outcome than SPT alone. Our goal was to determine whether combined pregabalin and SPT is more effective than SPT alone.

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          Author and article information

          Journal
          Chest
          Chest
          1931-3543
          0012-3692
          Mar 2016
          : 149
          : 3
          Affiliations
          [1 ] Speech Pathology Department, John Hunter Hospital, Hunter New England Health, Newcastle, Australia; Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia; University of Newcastle, Newcastle, Australia. Electronic address: anne.vertigan@hnehealth.nsw.gov.au.
          [2 ] Speech Pathology Department, John Hunter Hospital, Hunter New England Health, Newcastle, Australia; Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia.
          [3 ] Department of Toxicology & Pharmacology, The University of Newcastle, Calvary Mater Newcastle, Newcastle, Australia.
          [4 ] Division of Asthma, Allergy and Lung Biology, King's College Hospital, London, England.
          [5 ] University of Newcastle, Newcastle, Australia.
          [6 ] Speech Pathology Department, John Hunter Hospital, Hunter New England Health, Newcastle, Australia; Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia; University of Newcastle, Newcastle, Australia; Department of Respiratory & Sleep Medicine, John Hunter Hospital, Newcastle, Australia.
          Article
          S0012-3692(15)00046-X
          10.1378/chest.15-1271
          26447687
          b4ad90bc-ad6a-47d1-a8e6-ba5b514020ae
          Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.
          History

          cough,dyspnea,hoarseness,vocal cord dysfunction,voice disorders

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