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      Mast cells in the development of adaptive immune responses.

      1 , ,
      Nature immunology
      Springer Science and Business Media LLC

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          Abstract

          Mast cells are so widely recognized as critical effector cells in allergic disorders and other immunoglobulin E-associated acquired immune responses that it can be difficult to think of them in any other context. However, mast cells also can be important as initiators and effectors of innate immunity. In addition, mast cells that are activated during innate immune responses to pathogens, or in other contexts, can secrete products and have cellular functions with the potential to facilitate the development, amplify the magnitude or regulate the kinetics of adaptive immune responses. Thus, mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings.

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          Author and article information

          Journal
          Nat Immunol
          Nature immunology
          Springer Science and Business Media LLC
          1529-2908
          1529-2908
          Feb 2005
          : 6
          : 2
          Affiliations
          [1 ] Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5324, USA. sgalli@stanford.edu
          Article
          ni1158
          10.1038/ni1158
          15662442
          b4c782db-26b5-4da5-8df9-e4e6f65b5a1e
          History

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