Article Information
Accepted for Publication: December 19, 2019.
Published: February 26, 2020. doi:10.1001/jamanetworkopen.2020.0023
Open Access: This is an open access article distributed under the terms of the
CC-BY License. © 2020 Arbeev KG et al.
JAMA Network Open.
Corresponding Author: Konstantin G. Arbeev, PhD, Biodemography of Aging Research Unit, Social Science Research
Institute, Duke University, 2024 W Main St, Durham, NC 27705 (
ka29@
123456duke.edu
).
Author Contributions: Dr Arbeev and Ms Bagley had full access to all of the data in the study and take
responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Arbeev, Kark, Reiner, Christensen, Aviv.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Arbeev, Verhulst, Kark, Bagley, Aviv.
Critical revision of the manuscript for important intellectual content: Arbeev, Steenstrup, Kark, Kooperberg, Reiner, Hwang, Levy, Fitzpatrick, Christensen,
Yashin, Aviv.
Statistical analysis: Arbeev, Verhulst, Steenstrup, Bagley, Hwang, Christensen.
Obtained funding: Fitzpatrick, Yashin, Aviv.
Administrative, technical, or material support: Yashin, Aviv.
Supervision: Arbeev, Aviv.
Conflict of Interest Disclosures: Drs Hwang and Levy reported being employees of the National Heart, Lung, and Blood
Institute and that their research is supported by its Division of Intramural Research.
Dr Fitzpatrick reported receiving grants from National Institutes of Health during
the conduct of the study. Dr Yashin reported receiving grants from the National Institutes
of Health during the conduct of the study. Dr Aviv reported receiving grants from
National Institutes of Health during the conduct of the study. No other disclosures
were reported.
Funding/Support: This work was supported in part by contract N01-HC-25195 from the
National Heart, Lung, and Blood Institute for the Framingham Heart Study. The Cardiovascular Health Study research was supported
by contracts HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222,
N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086 and grants
U01HL080295 and U01HL130114 from the
National Heart, Lung, and Blood Institute, with additional contributions from the
National Institute of Neurological Disorders and Stroke. Additional support was provided by grant R01AG023629 from the
National Institute on Aging. The Women’s Health Initiative program is funded through contracts HHSN268201600018C,
HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C from
the
National Heart, Lung, and Blood Institute. Drs Arbeev and Yashin and Ms Bagley were partially supported by grant P01AG043352
from the
National Institutes of Health. Dr Aviv was supported by grants R01HL116446, R01HD071180, and R01HL13840 from the
National Institutes of Health and grants 262700 and 262043 from the
Norwegian Institute of Public Health. Drs Fitzpatrick and Aviv were supported by R01 HL80698 from the
National Institutes of Health.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management,
analysis, and interpretation of the data; preparation, review, or approval of the
manuscript; and decision to submit the manuscript for publication.
Disclaimer: The views expressed in this article are those of the authors and do not necessarily
represent the views of the National Heart, Lung, and Blood Institute; the National
Institutes of Health; or the US Department of Health and Human Services.
Additional Information: We dedicate this article to Jeremy D. Kark, MD, MPH—the epitome of a clinical researcher—who
inspired his colleagues and students in his uncompromised quest for the truth. Jeremy
sadly died while working on this study.