Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women

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Abstract

Background

Aging is known to be associated with increased risk of lipid disorders related to the development of type 2 diabetes. Recent evidence revealed that change of lipid molecule species in blood is associated with the risk of type 2 diabetes. However, changes in lipid molecular species induced by aging are still unknown.

We assessed the effects of age on the serum levels of lipid molecular species as determined by lipidomics analysis.

Methods

Serum samples were collected from ten elderly men (71.7 ± 0.5 years old) and women (70.2 ± 1.0 years old), ten young men (23.9 ± 0.4 years old), and women (23.9 ± 0.7 years old). Serum levels of lipid molecular species were determined by liquid chromatography mass spectrometry-based lipidomics analysis.

Results

Our mass spectrometry analysis revealed increases in the levels of multiple triacylglycerol molecular species in the serum of elderly men and women. Moreover, serum levels of total ester-linked phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were increased by aging. In contrast, serum levels of specific ether-linked PC and PE molecular species were lower in elderly individuals than in young individuals.

Conclusions

Our finding indicates that specific lipid molecular species, such as ether- and ester- linked phospholipids, may be selectively altered by aging.

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Most cited references 17

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Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

Haiming Cao, Kristin A. Gerhold, Jared Mayers … (2008)

Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid signals. A robust increase in de novo lipogenesis rendered the adipose tissue of these mice resistant to the deleterious effects of dietary lipid exposure. Systemic lipid profiling also led to identification of C16:1n7-palmitoleate as an adipose tissue-derived lipid hormone that strongly stimulates muscle insulin action and suppresses hepatosteatosis. Our data reveal a lipid-mediated endocrine network and demonstrate that adipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regulate systemic metabolic homeostasis.

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Role of cholesterol and lipid organization in disease.

Frederick Maxfield, Ira Tabas (2005)

Membrane lipids are essential for biological functions ranging from membrane trafficking to signal transduction. The composition of lipid membranes influences their organization and properties, so it is not surprising that disorders in lipid metabolism and transport have a role in human disease. Significant recent progress has enhanced our understanding of the molecular and cellular basis of lipid-associated disorders such as Tangier disease, Niemann-Pick disease type C and atherosclerosis. These insights have also led to improved understanding of normal physiology.

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Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.

William Holland, Scott Summers (2008)

Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and cardiovascular disease. Sphingolipids such as ceramide and glucosylceramides, while being a relatively minor component of the lipid milieu in most tissues, may be among the most pathogenic lipids in the onset of the sequelae associated with excess adiposity. Circulating factors associated with obesity (e.g., saturated fatty acids, inflammatory cytokines) selectively induce enzymes that promote sphingolipid synthesis, and lipidomic profiling reveals relationships between tissue sphingolipid levels and certain metabolic diseases. Moreover, studies in cultured cells and isolated tissues implicate sphingolipids in certain cellular events associated with diabetes and cardiovascular disease, including insulin resistance, pancreatic beta-cell failure, cardiomyopathy, and vascular dysfunction. However, definitive evidence that sphingolipids contribute to insulin resistance, diabetes, and atherosclerosis has come only recently, as researchers have found that pharmacological inhibition or genetic ablation of enzymes controlling sphingolipid synthesis in rodents ameliorates each of these conditions. Herein we will review the role of ceramide and other sphingolipid metabolites in insulin resistance, beta-cell failure, cardiomyopathy, and vascular dysfunction, focusing on these in vivo studies that identify enzymes controlling sphingolipid metabolism as therapeutic targets for combating metabolic disease.

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Author and article information

Contributors

Noriaki Kawanishi: kawanishi.noriaki@p.chibakoudai.jp

Yuki Kato: utree28-kato@akane.waseda.jp

Kyosuke Yokozeki: yokozeki@fuji.waseda.jp

Shuji Sawada: shu-sawada@ruri.waseda.jp

Ryota Sakurai: r_sakurai@hotmail.co.jp

Yoshinori Fujiwara: fujiwayo@tmig.or.jp

Shoji Shinkai: sshinkai@tmig.or.jp

Nobuhito Goda: goda@waseda.jp

Katsuhiko Suzuki: katsu.suzuki@waseda.jp

Journal

Journal ID (nlm-ta): Lipids Health Dis

Journal ID (iso-abbrev): Lipids Health Dis

Title: Lipids in Health and Disease

Publisher: BioMed Central (London )

ISSN (Electronic): 1476-511X

Publication date (Electronic): 6 June 2018

Publication date PMC-release: 6 June 2018

Publication date Collection: 2018

Volume: 17

Electronic Location Identifier: 135

Affiliations

[1 ]ISNI 0000 0004 1936 9975, GRID grid.5290.e, Institute for Nanoscience & Nanotechnology, , Waseda University, ; 513, Tsurunomaki, Waseda, Shinjuku-ku, Tokyo, 162-0041 Japan

[2 ]Chiba Institute of Technology, Faculty of Advanced Engineering, Narashino, Chiba, Japan

[3 ]ISNI 0000 0004 1762 2738, GRID grid.258269.2, Guraduate School of Health and Sports Science, , Juntendo University, ; Inzai, Chiba, Japan

[4 ]ISNI 0000 0004 1936 9975, GRID grid.5290.e, Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, , Waseda University, ; Shinjuku-ku, Tokyo, Japan

[5 ]ISNI 0000 0004 1936 9975, GRID grid.5290.e, Faculty of Sports Science, , Waseda University, ; Tokorozawa, Saitama, Japan

[6 ]ISNI 0000 0000 9337 2516, GRID grid.420122.7, Research Team for Social Participation and Community Health, , Tokyo Metropolitan Institute of Gerontology, ; Itabashi-ku, Tokyo, Japan

Article

Publisher ID: 785

DOI: 10.1186/s12944-018-0785-6

PMC ID: 5991438

PubMed ID: 29875018

SO-VID: b4cb4e5c-86ef-4055-ac27-b93fa7deb738

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 19 September 2017

Date accepted : 21 May 2018

Funding

Funded by: Grant-in Aid for Scientific Research (A) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

Custom metadata

ScienceOpen disciplines: Biochemistry

Keywords: aging,lipidomics,lipid,molecular species

Data availability:

ScienceOpen disciplines: Biochemistry

Keywords: aging, lipidomics, lipid, molecular species

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Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women

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Abstract

Background

Methods

Results

Conclusions

Related collections

Journal of Circulating Biomarkers

Most cited references 17

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

Role of cholesterol and lipid organization in disease.

Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.

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Contributors

Journal

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Article

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Cited by 14

Most referenced authors 528