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      Reactivity of Aorta and Portal Vein in Germfree Rats

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          The responsiveness of conventional and germfree rat aortas and portal veins to vasoactive agents were compared in vitro. The results indicate: (1) aortas and portal veins from germfree rats exhibit an attenuated reactivity to angiotensin, vasopressin and epinephrine but not to KC1; (2) the dose-response curves for epi-nephrine and the peptides were shifted to the right concomitant with a decrease in maximum contractile tension, and (3) CaCl<sub>2</sub> dose-response curves obtained on potassium-depolarized aorta were not different from one another, whereas those obtained on portal veins from germfree animals were shifted to the right with a concomitant decrease in maximum response. In addition, aortas and portal veins from germfree rats were found to exhibit a higher total Ca content (but not Mg or water) when compared to conventional animals.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 12
          : 4
          : 206-218
          Departments of Anesthesiology and Physiology, Albert Einstein College of Medicine of Yeshiva University, Bronx, N.Y., and Department of Physiology, State University of New York Downstate Medical Center, Brooklyn, N.Y.
          158057 Blood Vessels 1975;12:206–218
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 13


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