Effects of Intraventricular Infusions of 6-Hydroxydopamine (6-OHDA) on Pituitary LH Release and Ovulation in the Rabbit

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Abstract

Repeated infusions of 6-hydroxydopamine (6-OHDA) into the third ventricle of the rabbit brain in dosages shown to depress hypothalamic norepinephrine (NE) by more than 80% failed to block the copulation-induced ovulatory surge of LH release from the adenohypophysis in estrogen-primed, multiparous New Zealand White does. Only when infusion of the neurotoxin produced a basal hypothalamic lesion did it intercept the coital stimulus and prevent LH release. In 5 rabbits the initial infusion of 6-OHDA stimulated an LH surge presumably by activating NE release from noradrenergic nerve endings. The failure of chronic depletion of hypothalamic NE to prevent coitally-induced LH release suggests that the transmitter may normally play only a modulatory role in hypothalamopituitary activation in the reflex ovulator, as has also been proposed for its function in cyclic ovulation in the rat. The results suggest that alternative systems may be brought into play to subserve reproductive mechanisms when hypothalamic NE is chronically depleted.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1980

Publication date (Print): 1980

Publication date (Electronic): 26 March 2008

Volume: 30

Issue: 6

Pages: 362-368

Affiliations

Department of Anatomy and Brain Research Institute, UCLA School of Medicine, Los Angeles, Calif.

Article

Publisher ID: 123035 Other ID: Neuroendocrinology 1980;30:362–368

DOI: 10.1159/000123035

PubMed ID: 7383275

SO-VID: b4e8ed8f-4a92-4ca7-a84b-4b7a19bba54e

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 03 July 1979

Date accepted : 23 October 1979

Page count

Pages: 7

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