Heart conduction disorders related to antimalarials toxicity: an analysis of electrocardiograms in 85 patients treated with hydroxychloroquine for connective tissue diseases.

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Abstract

The antimalarial agents chloroquine (CQ) and hydroxychloroquine (HCQ) are used in long-term treatment of connective tissue diseases (CTDs). A high incidence of heart conduction disorders, including bundle-branch block and incomplete or complete atrioventricular block, has been observed among patients treated with CQ. Since no data were available for HCQ, we studied electrocardiograms (ECGs) in 85 unselected patients with CTD treated with HCQ as the sole antimalarial.

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Journal

Journal ID (iso-abbrev): Rheumatology (Oxford)

Title: Rheumatology (Oxford, England)

Publisher: Oxford University Press (OUP)

ISSN: 1462-0324

ISSN (Print): 1462-0324

Publication date (Electronic): May 2007

Volume: 46

Issue: 5

Affiliations

[1 ] AP-HP Service de Médecine Interne, Centre de Référence National pour les Lupus et le Syndrome des Antiphospholipides, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris Cedex 13, France. nathalie.costedoat@psl.aphp.fr

Article

Publisher Item ID: kel402

DOI: 10.1093/rheumatology/kel402

PubMed ID: 17202178

SO-VID: b5092579-efd2-4561-91b5-ce789eb1bc1f

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