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      Effectiveness of a pharmacist-led quality improvement program to reduce medication errors during hospital discharge

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          Abstract

          Background:

          Patients requiring medications during discharge are at risk of discharge medication errors that potentially cause readmission due to medication-related events.

          Objective:

          The objective of this study was to develop interventions to reduce percentage of patients with one or more medication errors during discharge.

          Methods:

          A pharmacist-led quality improvement (QI) program over 6 months was conducted in medical wards at a tertiary public hospital. Percentage of patients discharge with one or more medication errors was reviewed in the pre-intervention and four main improvements were developed: increase the ratio of pharmacist to patient, prioritize discharge prescription order within office hours, complete discharge medication reconciliation by ward pharmacist, set up a Centralized Discharge Medication Pre-packing Unit. Percentage of patients with one or more medication errors in both pre- and post-intervention phase were monitored using process control chart.

          Results:

          With the implementation of the QI program, the percentage of patients with one or more medication errors during discharge that were corrected by pharmacists significantly increased from 77.6% to 95.9% (p<0.001). Percentage of patients with one or more clinically significant error was similar in both pre and post-QI with an average of 24.8%.

          Conclusions:

          Increasing ratio of pharmacist to patient to complete discharge medication reconciliation during discharge significantly recorded a reduction in the percentage of patients with one or more medication errors.

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          Most cited references37

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          Medication reconciliation during transitions of care as a patient safety strategy: a systematic review.

          Medication reconciliation identifies and resolves unintentional discrepancies between patients' medication lists across transitions in care. The purpose of this review is to summarize evidence about the effectiveness of hospital-based medication reconciliation interventions. Searches encompassed MEDLINE through November 2012 and EMBASE and the Cochrane Central Register of Controlled Trials through July 2012. Eligible studies evaluated the effects of hospital-based medication reconciliation on unintentional discrepancies with nontrivial risks for harm to patients or 30-day postdischarge emergency department visits and readmission. Two reviewers evaluated study eligibility, abstracted data, and assessed study quality. Eighteen studies evaluating 20 interventions met the selection criteria. Pharmacists performed medication reconciliation in 17 of the 20 interventions. Most unintentional discrepancies identified had no clinical significance. Medication reconciliation alone probably does not reduce postdischarge hospital utilization but may do so when bundled with interventions aimed at improving care transitions.
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            Effect of an In-Hospital Multifaceted Clinical Pharmacist Intervention on the Risk of Readmission

            Hospital readmissions are common among patients receiving multiple medications, with considerable costs to the patients and society.
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              Classifying and predicting errors of inpatient medication reconciliation.

              Failure to reconcile medications across transitions in care is an important source of potential harm to patients. Little is known about the predictors of unintentional medication discrepancies and how, when, and where they occur. To determine the reasons, timing, and predictors of potentially harmful medication discrepancies. Prospective observational study. Admitted general medical patients. Study pharmacists took gold-standard medication histories and compared them with medical teams' medication histories, admission and discharge orders. Blinded teams of physicians adjudicated all unexplained discrepancies using a modification of an existing typology. The main outcome was the number of potentially harmful unintentional medication discrepancies per patient (potential adverse drug events or PADEs). Among 180 patients, 2066 medication discrepancies were identified, and 257 (12%) were unintentional and had potential for harm (1.4 per patient). Of these, 186 (72%) were due to errors taking the preadmission medication history, while 68 (26%) were due to errors reconciling the medication history with discharge orders. Most PADEs occurred at discharge (75%). In multivariable analyses, low patient understanding of preadmission medications, number of medication changes from preadmission to discharge, and medication history taken by an intern were associated with PADEs. Unintentional medication discrepancies are common and more often due to errors taking an accurate medication history than errors reconciling this history with patient orders. Focusing on accurate medication histories, on potential medication errors at discharge, and on identifying high-risk patients for more intensive interventions may improve medication safety during and after hospitalization.
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                Author and article information

                Contributors
                Journal
                Pharm Pract (Granada)
                Pharm Pract (Granada)
                Pharmacy Practice
                Centro de Investigaciones y Publicaciones Farmaceuticas
                1885-642X
                1886-3655
                Jul-Sep 2019
                21 August 2019
                : 17
                : 3
                : 1501
                Affiliations
                Pharmacy Department, Raja Permaisuri Bainun Hospital; &. Discipline of Social & Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia . Penang (Malaysia). doris.moh.gov@ 123456gmail.com
                Pharmacy Department, Raja Permaisuri Bainun Hospital . Perak (Malaysia). nmala_15@ 123456yahoo.com
                Pharmacy Department, Raja Permaisuri Bainun Hospital . Perak (Malaysia). qurasyiah@ 123456gmail.com
                Discipline of Social & Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia . Penang (Malaysia). azmihassali@ 123456gmail.com
                Center for Clinical Epidemiology, Institute for Clinical Research, National Institutes of Health , Ministry of Health. Selangor (Malaysia). amanda.limwy.crc@ 123456gmail.com
                Pediatric Department, Raja Permaisuri Bainun Hospital , Ministry of Health. Perak (Malaysia). amarhss@ 123456gmail.com
                Author information
                http://orcid.org/0000-0001-8476-999X
                http://orcid.org/0000-0002-1506-7166
                http://orcid.org/0000-0002-6956-116X
                http://orcid.org/0000-0001-9575-403X
                http://orcid.org/0000-0002-2612-0604
                http://orcid.org/0000-0001-7426-1551
                Article
                pharmpract-17-1501
                10.18549/PharmPract.2019.3.1501
                6763293
                b5146ca0-ddc1-45a8-9ecd-efd06b6cc3b9
                Copyright: © Pharmacy Practice

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY-NC-ND 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 20 March 2019
                : 05 August 2019
                Categories
                Original Research

                patient discharge,medication reconciliation,medication errors,prescriptions,pharmacy service,hospital,pharmacists,quality assurance,health care,malaysia

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